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Ankylosing spondylitis (AS) is the prototypical example of an human leukocyte antigen (HLA) -B27-associated rheumatic disease. Recently, we confirmed that HLA-B60 is also genetic risk factor for AS (OR in meta-analysis 2.2; 95% CI 1.8 to 2.8).1
Moreover, while 18% of AS patients had both HLA-B27 and HLA-B60, this combination of two HLA-alleles in one person (HLA-B27/HLA-B60) was very rare in blood donors (0.4%). As a result, individuals with the HLA-B27/HLA-B60 genotype are at a very high risk of developing AS.1 Acute anterior uveitis (AAU) may complicate AS but is also an HLA-B27-associated disease in itself.2 Given that AAU share clinical and genetic features with AS, we investigated if HLA-B60 is a risk factor for AAU.
Patients were found by retrospective review of …
Contributors Conception: FAVG, REMT; Design: FAvG, TWJH, DvdH, REMT; Analysis: FAVG, WV, DLR; Interpretation: FAVG, WV, DLR, TWJH, DvdH, REMT; Drafting the article and revising the article, including the final version: FAVG, WV, DLR, TWJH, DVdH, REMT.
Competing interests None.
Funding REMT's work is supported by an NWO-ZonMW VICI grant from the Dutch Organization for Scientific Research.
Patient consent HLA typing was performed for diagnostic purposes for which all patients gave their consent. This non-interventional, retrospective study was performed in accordance with Dutch patient protection law.
Provenance and peer review Not commissioned; externally peer reviewed.
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