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We investigated whether a delayed treat-to-target strategy introduction was disadvantageous compared with the clinical, radiological, and functional efficacy of initial introduction on early rheumatoid arthritis (RA) after a 3-year follow-up (T-4 3-year) study.
Between August 2008 and April 2010, 243 early RA patients (symptom duration <3 years) were randomly allocated to one of four strategy groups; we focus here on the routine care (R group) and the disease activity score in 28 joints (DAS28)1 plus matrix metalloproteinase (MMP)-3-driven therapy (T group)2 (figure 1).3 The T-4 3-year study followed a 1-year study. At 56 weeks, all subjects were allocated to the T group (R→T, RT group; T→T, TT group, etc.), and visits were every 4 weeks; the clinical variable assessment, each physician's articular examination and DAS28 calculations were every 12 weeks and at baseline.
Contributors Study conception and design: YU and K-iF. Acquisition of data: YU and YN. Analysis and interpretation of data: YU and K-iF.
Competing interests None.
Patient consent Obtained.
Ethics approval The study protocol was approved by the institutional review committee at each participating centre.
Provenance and peer review Not commissioned; externally peer reviewed.
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