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  • Response to: ‘Obesity and comorbidity are independently associated with a failure to achieve remission in patients with established rheumatoid arthritis’ by Ellerby et al

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Correspondence response
Response to: ‘Obesity and comorbidity are independently associated with a failure to achieve remission in patients with established rheumatoid arthritis’ by Ellerby et al
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  1. Maria E C Sandberg1,
  2. Camilla Bengtsson1,
  3. Henrik Källberg1,
  4. Annmarie Wesley1,
  5. Lars Klareskog2,
  6. Lars Alfredsson1,
  7. Saedis Saevarsdottir1,2
  1. 1Department of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
  2. 2Department of Rheumatology, Karolinska Institutet, Stockholm, Sweden
  1. Correspondence to Dr Maria E C Sandberg, Department of Environmental Medicine, Karolinska Institutet, Nobelsv. 13, Stockholm 171 77, Sweden; maria.sandberg{at}ki.se

https://doi.org/10.1136/annrheumdis-2014-206369

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    We thank Ellerby et al1 for their interest in our manuscript addressing the effect of obesity on the prognosis of rheumatoid arthritis (RA), and for sharing their own data. We are happy to see Ellerby and colleagues’ findings in the later phase of RA to be in accordance with our own findings in early RA,2 and to confirm findings by Ajeganova et al3 who have shown a similar effect of obesity in patients with longstanding RA. We are, as Ellerby and colleagues are, also very interested in the underlying biological mechanism for these findings. Further, we look forward to upcoming initiatives to clinically study whether this link between obesity and decreased chance of good response and remission can be countered by a voluntary weight decrease during the disease course.

    References

    1. ↵
      1. Ellerby N,
      2. Mattey DL,
      3. Packham J, et al
      . Obesity and comorbidity are independently associated with a failure to achieve remission in patients with established rheumatoid arthritis. Ann Rheum Dis 2014;73:e74.
    2. ↵
      1. Sandberg ME,
      2. Bengtsson C,
      3. Kallberg H, et al
      . Overweight decreases the chance of achieving good response and low disease activity in early rheumatoid arthritis. Ann Rheum Dis 2014;73:2029–33.
    3. ↵
      1. Ajeganova S,
      2. Andersson ML,
      3. Hafstrom I
      . Association of obesity with worse disease severity in rheumatoid arthritis as well as with comorbidities: a long-term followup from disease onset. Arthritis Care Res (Hoboken) 2013;65:78–87.
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    Footnotes

    • Contributors LA and SS contributed equally.

    • Competing interests None.

    • Provenance and peer review Commissioned; internally peer reviewed.

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