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Recurrent idiopathic pericarditis is a common, problematic complication of acute pericarditis, occurring in approximately 30% of cases.1 Despite appropriate management with non-steroidal anti-inflammatory drugs (NSAIDs), colchicine and corticosteroids (CS), a number of patients are either resistant to treatment requiring long-term therapy with high doses of CS or intolerant to therapy.2–4
This disease is currently viewed as an autoinflammatory disease based on its clinical and laboratory features (recurrent episodes of sterile serosal inflammation in the absence of specific autoreactive antibodies or T cells),5–7 and the preliminary results showing favourable response to intereleukin-1 (IL-1) inhibition.8–10 Anakinra, a known IL-1 receptor antagonist, has been successfully used in small series of paediatric patients8 ,9 while we have recently first reported its efficacy and safety in three adult patients.10 In this report, we extend our follow-up on these three patients, and present data on seven more adult patients treated with anakinra. …
Contributors GL: participated in study design and supervision; data acquisition, analysis and interpretation; and drafting, revision and final approval of the report; PV: participated in data acquisition, analysis and interpretation; drafting, revision and final approval of the manuscript; CK and KA: participated in data acquisition; drafting, revision and final approval of the manuscript; CS and DP: participated in study supervision; data interpretation; and drafting, revision and final approval of the report; DV: participated in study conception, design and supervision; data acquisition, analysis and interpretation; and drafting, revision and final approval of the report.
Funding Special Account for Research Grants (SARG), National and Kapodistrian University of Athens, Athens, Greece.
Competing interests None.
Ethics approval Institutional Review Board, Hippokration General Hospital.
Provenance and peer review Not commissioned; externally peer reviewed.
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