Article Text

Correspondence response
Response to: ‘IL-23 expression and activation of autophagy in synovium and PBMCs of HLA-B27 positive patients with ankylosing spondylitis‘ by Neerinckx et al.
  1. Francesco Ciccia,
  2. Riccardo Alessandro,
  3. Giovanni Triolo
  1. University of Palermo, Palermo, Italy
  1. Correspondence to Dr Francesco Ciccia, University of Palermo, Palermo 90127, Italy; francescociccia{at}

Statistics from

We read with interest the study by Neerinckx et al1 addressing the expression of interleukin (IL)-23p19 and of autophagy genes in the synovium and in the peripheral blood mononuclear cells of patients with ankylosing spondylitis (AS). Differently from our observation in the gut,2 the authors failed to demonstrate any significant increase by RT-PCR in the expression of synovium autophagy-related genes (ATG16L1, IRGM, MAP1LC3A, ATG5, HSPA8 and HSP90AA1) together with no significant overexpression of IL-23p19 compared with disease and healthy controls.

We have previously demonstrated by immunohistochemistry that in the …

View Full Text

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Linked Articles