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Treatment of chronic hepatitis C complicated by mixed cryoglobulinemia with new protease inhibitor, sofosbuvir
  1. Jonathan G Stine,
  2. Scott Cornella,
  3. Neeral L Shah
  1. Correspondence to Dr Jonathan G Stine, University of Virginia, USA; jgs9f{at}

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Article citation: Saadoun D, Rigon MR, Thibault V, et al. Peg-IFNα/ribavirin/protease inhibitor combination in hepatitis C virus associated mixed cryoglobulinemia vasculitis: results at week 24. Ann Rheum Dis 2014;73:831–7.

The lack of data showing the effective clearance of cryoglobulins with the addition of direct acting antiviral drugs is problematic, where close to 50% of patients with chronic hepatitis C (HCV) have cryoglobulinemia.1 The original article by Saadoun et al.2 is timely and sheds light on this large subset of chronic HCV …

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  • Competing interests None.

  • Provenance and peer review Not commissioned; internally peer reviewed.

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