Heightened immune response to autocitrullinated Porphyromonas gingivalis peptidylarginine deiminase: a potential mechanism for breaching immunologic tolerance in rheumatoid arthritis

Anne-Marie Quirke; Elena Birgitta Lugli; Natalia Wegner; Bart C Hamilton; Peter Charles; Muslima Chowdhury; A Jimmy Ytterberg; Roman A Zubarev; Jan Potempa; Shauna Culshaw; Yonghua Guo; Benjamin A Fisher; Geoffrey Thiele; Ted R Mikuls; Patrick JW Venables

doi:10.1136/annrheumdis-2012-202726

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Heightened immune response to autocitrullinated Porphyromonas gingivalis peptidylarginine deiminase: a potential mechanism for breaching immunologic tolerance in rheumatoid arthritis

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Anne-Marie Quirke Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, London, UK PubMed articles Google scholar articles
Elena Birgitta Lugli Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, London, UK PubMed articles Google scholar articles
Natalia Wegner Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, London, UK PubMed articles Google scholar articles
Bart C Hamilton Department of Medicine, University of Nebraska Medical Center and Omaha VA Medical Center, Wittson Hall, USA PubMed articles Google scholar articles
Peter Charles Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, London, UK PubMed articles Google scholar articles
Muslima Chowdhury Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, London, UK PubMed articles Google scholar articles
A Jimmy Ytterberg Deparment of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden PubMed articles Google scholar articles
Roman A Zubarev Deparment of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden PubMed articles Google scholar articles
Jan Potempa Faculty of Biochemistry, Biophysics and Biotechnology, Department of Microbiology, Jagiellonian University, Krakow, Poland Oral Health and Systemic Research Group, University of Louisville, School of Dentistry, Louisville, USA PubMed articles Google scholar articles
Shauna Culshaw Infection and Immunity, University of Glasgow Dental School, School of Medicine, College of Veterinary, Medical and Life Sciences, University of Glasgow, Glasgow, UK PubMed articles Google scholar articles
Yonghua Guo Oral Health and Systemic Research Group, University of Louisville, School of Dentistry, Louisville, USA PubMed articles Google scholar articles
Benjamin A Fisher Rheumatology Research Group, Centre for Translational Inflammation Research, University of Birmingham, Birmingham, UK PubMed articles Google scholar articles
Geoffrey Thiele Department of Medicine, University of Nebraska Medical Center and Omaha VA Medical Center, Wittson Hall, USA PubMed articles Google scholar articles
Ted R Mikuls Department of Medicine, University of Nebraska Medical Center and Omaha VA Medical Center, Wittson Hall, USA PubMed articles Google scholar articles
Patrick JW Venables Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, London, UK PubMed articles Google scholar articles

Correspondence to Professor Patrick JW Venables, University of Oxford, Kennedy Institute of Rheumatology, 65 Aspenlea road, London W6 8RF, UK; patrick.venables{at}kennedy.ox.ac.uk

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Quirke A, Lugli EB, Wegner N, et al

Heightened immune response to autocitrullinated Porphyromonas gingivalis peptidylarginine deiminase: a potential mechanism for breaching immunologic tolerance in rheumatoid arthritis

Annals of the Rheumatic Diseases 2014;73:263-269.

Publication history

Received September 24, 2012
Revised January 8, 2013
Accepted February 3, 2013
First published March 5, 2013.

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December 04, 2013

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