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Bone remodelling in inflammatory arthritis
  1. Steven R Goldring1,
  2. P Edward Purdue1,
  3. Tania N Crotti2,
  4. Zhenxin Shen3,
  5. Merrilee R Flannery3,
  6. Nikolaus B Binder1,
  7. F Patrick Ross1,
  8. Kevin P McHugh4
  1. 1Research Division, Hospital for Special Surgery, Weill Cornell Medical College, New York, USA
  2. 2Discipline of Anatomy and Pathology, University of Adelaide, Adelaide, South Australia, Australia
  3. 3Department of Orthopaedic Surgery, Center for Advanced Orthopaedic Studies, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
  4. 4Department of Periodontology, College of Dentistry, University of Florida, Gainesville, Florida, USA
  1. Correspondence to Dr Steven R Goldring, Department of Medicine, Hospital for Special Surgery, Weill Cornell Medical College, 535 East 70th Street, New York, NY 10128, USA; goldrings{at}


The inflammatory arthropathies that include rheumatoid arthritis, the seronegative spondyloarthropathies and systemic lupus erythematosus are characterised by marked alterations in the architecture and structural integrity of peri-articular bone; however, the pattern and natural history of the skeletal changes differs in these conditions. In part, this can be attributed to differences in the primary anatomical site of the inflammation, but also there is evidence that there are differences in the biological properties and products produced by inflammatory tissues. This review will focus on recent advances in the understanding of the cellular and molecular mechanisms that contribute to the differential pattern of articular bone remodelling in these prototypical inflammatory forms of arthritis.

  • Arthritis
  • Inflammation
  • Treatment
  • Rheumatoid Arthritis
  • Spondyloarthritis

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