Article Text

Download PDFPDF
SAT0202 Early Accrual of Organ Damage in Systemic Sclerosis: Rationale for Forming a Multinational Inception Cohort of Patients with Scleroderma (The Insync Study)
  1. M. Nikpour1,
  2. M. Baron2,
  3. M. Hudson3,
  4. P. Carreira4,
  5. N. Hunzelmann5,
  6. T. Frech6,
  7. J. Sahhar7,
  8. P. Nash8,
  9. J. Roddy9,
  10. L. Schrieber10,
  11. W. Stevens1,
  12. S. Proudman11
  1. 1St. Vincent’s Hospital, Melbourne, Australia
  2. 2Jewish General Hospital
  3. 3Lady Davis Institute for Medical Research, Montreal, Canada
  4. 4Hospital Universitário, Madrid, Spain
  5. 5University of Cologne, Cologne, Germany
  6. 6University of Utah, Salt Lake City, United States
  7. 7Monash Medical Centre, Melbourne
  8. 8Sunshine Coast Rheumatology, Maroochydore
  9. 9Royal Perth Hospital, Perth
  10. 10Royal North Shore Hospital, Sydney
  11. 11Royal Adelaide Hospital, Adelaide, Australia


Background Systemic sclerosis (SSc) has the potential to result in irreversible damage in various organs.

Objectives To determine the accrual of damage in each organ system in the first five years of SSc disease.

Methods A panel of experts defined organ-specific indicators of damage in SSc. Using prospectively acquired data from patients entering the Australian Scleroderma Cohort Study within 2 years of disease onset, annual accrual of organ damage from years 2 to 5 following disease onset was determined.

Results The frequency of each damage indicator at years 2 to 5 in 182 patients is presented in the graph. Damage occurred in all organ systems, most commonly in the skin/MSK (23.1% at 4 years), respiratory (12.1%), GI (7.1%) & GU systems (erectile dysfunction in men 31.4%).

Conclusions Organ damage occurs early in SSc. This is a compelling rationale for forming a large inception cohort (INternational SYstemic Sclerosis Inception Cohort; INSYNC) of patients with SSc to determine the predictors of organ damage and to develop strategies for preventing the occurrence of organ damage in SSc.

Disclosure of Interest None Declared

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.