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THU0495 Are Different Disease Subtypes with Distinct Clinical Expression Present in Familial Mediterranean Fever: Results of a Cluster Analysis
  1. S. Akar1,
  2. T. Kasifoglu2,
  3. D. Solmaz1,
  4. S. Y. Bilge2,
  5. I. Sari1,
  6. M. Tunca3
  1. 1Rhemautology, Dokuz Eylul University School of Medicine, Izmir
  2. 2Rhemautology, Osmangazi University School of Medicine, Eskisehir
  3. 3Internal Medicine, Dokuz Eylul University School of Medicine, Izmir, Turkey


Background Familial Mediterranean fever (FMF) is an auto-inflammatory disorder characterized by self limited attacks of fever and serositis. The disease expression may be different in different ethnic groups and patients with certain MEFV mutations may be prone to have more severe disease and a greater probability of developing amyloidosis (1). Recently we showed that amyloidosis is the only predictor of mortality in Turkish FMF patients (2), however clinical subtypes with different clinical and genetic characteristics have been never identified previously.

Objectives The aim of this study was to evaluate whether there are clinical subgroups, which may have different prognosis, among FMF patients.

Methods The cumulative clinical features of a large group of FMF patients (1168 patients, 575 female [49.2%] and mean age was 35.3 ± 12.4 years) were studied. To analyse our data and identify groups of FMF patients with similar clinical characteristics, a two-step cluster analysis using log-likelihood distance measures was performed. For clustering the FMF patients, we evaluated the following variables: gender, current age, age at symptom onset, age at diagnosis, the presence of major clinical features (fever, peritonitis, pleuritis, arthritis, erysipelas like erythema [ELE], febrile myalgia, amyloidosis), variables related with therapy (the dosage of colchicine, compliance with therapy, and the presence of attacks despite colchicine), the family history for FMF and for renal failure and the presence of M694V allele.

Results Three distinct clinical groups of FMF patients were identified. Cluster 1 was characterized by high prevalence of arthritis, pleuritis, ELE, and febrile myalgia. The dosage of colchicine and the frequency of amyloidosis were lower in cluster 1. Patients in cluster 2 had earlier age at symptom onset and diagnosis. Other characteristics of cluster 2 were high frequency of arthritis, amyloidosis, M694V allele and family history for FMF. This group of patients was using highest dose of colchicine. The cluster 3 was characterized by the lowest frequency of M694V allele, ELE, arthritis, protracted febrile myalgia. The colchicine resistance was also lower in cluster 3. The mean age and age at diagnosis was the highest in cluster 3.

Conclusions Patients with FMF could be clustered into distinct patterns of clinical and genetic manifestations and these patterns may have different prognostic significance.


  1. Touitou I, Sarkisian T, Medlej-Hashim M, Tunca M, Livneh A, Cattan D, et al. Country as the primary risk factor for renal amyloidosis in familial Mediterranean fever. Arthritis Rheum. 2007 May;56(5):1706-12.

  2. Akar S, Yuksel F, Tunca M, Soysal O, Solmaz D, Gerdan V, et al. Familial Mediterranean fever: risk factors, causes of death, and prognosis in the colchicine era. Medicine. 2012 May;91(3):131-6.

Disclosure of Interest None Declared

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