Article Text

THU0484 Impact of TNF Antagonists on the Joint Manifestations of Sarcoidosis
  1. C. Banse1,
  2. A. Bisson-Vaivre1,
  3. M. Kozyreff-Meurice1,
  4. S. Dominique1,
  5. O. Vittecoq1,
  6. V. Goeb2
  1. 1Rheumatology, Rouen
  2. 2Rheumatology, Amiens, France


Objectives Use of anti-TNF agents to treat joint manifestations of sarcoidosis has not been described. We evaluated the efficacy and safety of 3 such biologics in patients with these symptoms refractory to conventional therapy (NSAIDs, corticosteroids and/or DMARDs).

Methods This retrospective study, covering January 2001 to September 2011, examined the following clinical–biological parameters collected before anti-TNF treatment (age, sex, duration of disease evolution, drugs taken), and at introduction and under anti-TNF therapy (number of painful and swollen joints, visual analogue-scale score of global disease activity, Disease Activity Score-28 with ESR or CRP, TNF-antagonist duration). At 3, 6 and 12 months, anti-TNF impact on joints and the therapeutic response according to EULAR criteria used for rheumatoid arthritis were assessed.

Results Ten patients data were evaluated; some of them had received several anti-TNF agents (median (range) duration on each biotherapy was 10 (4–30) months), which enabled analysis of 19 prescriptions. The total duration of anti-TNF exposure was 17.6 patient-years, that was started a median of 3 (0.33–17) years after sarcoidosis diagnosis. The median numbers of painful and swollen joints were, respectively, 1 (0–28) and 0 (0–9). Despite rapid efficacy, after 1 year of treatment, clinical (especially joint) and biological parameters were comparable to pretreatment and only the corticosteroid dose was significantly lower (P = 0.03). One case of mild skin toxicity was noted.

Conclusions TNF antagonists allowed significant steroid-sparing and were well-tolerated but do not seem to be effective against sarcoidosis joint involvement.

Disclosure of Interest None Declared

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