Background Health-related quality of life (HRQoL) is an important domain in evaluation of health status of patients with systemic lupus erythematosus (SLE) and other connective tissue disorders (CTDs). It has been shown that HRQoL is lower in SLE and other CTDs compared to general population, but comparative data on HRQoL profiles in various CTDs in Russian patients is limited.
Objectives We aimed to determine HRQoL in Russian SLE patients and to compare HRQoL profiles with other CTDs patients.
Methods We used SF-36 to measure HRQoL in 129 SLE, 18 SSc, 12 PM/DM, and 25 SV patients. SF-36 scales were used to construct disease-specific HRQoL profile. ANOVA was performed to compare profiles, Spearman correlation and linear regression were used to find out determinants of SF-36 physical (PCS) and mental (MCS) component summary scores, p-values <0.05 regarded significant.
Results SLE patients had the following demographic and clinical features (M (SD)): age 35.67 (14.50); females 88.4%; disease duration (DD) 7.06 (6.68) years; activity scores SLAM 14.32 (6.79); SLEDAI-2K 8.76 (6.53); 91.5% received corticosteroids, 27.8% cytotoxic medications; damage by SLICC/ACR index 1.57 (1.55), 42 patients (32.6%) had no damage. SSc patients: age 48.67 (14.21); females 94.4%; DD 9.94 (10.43) years; 50% received corticosteroids. SV patients included 6 polyartereitis nodosum (24%), 12 Henoch-Shönlein vasculitis (48%), 2 Takayasu arteritis (8%), 3 Wegener’s granulomatosis (12%) and 2 Churg-Strauss syndrome (8%) patients. Among PM/DM patients 9 (75%) were female, age 55.25 (12.12) years, DD 1.6 (1.91) years, all on corticosteroids.
Results for profiling of HRQoL according to SF-36 scales of Physical Functioning (PF), Role-Physical Functioning (RP), Bodily pain (BP), General Health (GH), Vitality (VT), Social Functioning (SF), Role-Emotional (RE), Mental Health (MH) are shown in the table.
Conclusions HRQoL is lower in SLE and other CTDs compared to general population. HQRoL profiles are different in CTD patients. Those differences are important considerations when evaluating patients in routine practice and clinical trials. A restricted set of demographical and clinical parameters is responsible for HRQoL determinants.
Disclosure of Interest None Declared
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