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Associations of CTX-II with biochemical markers of bone turnover raise questions about its tissue origin: data from CHECK, a cohort study of early osteoarthritis
  1. Harry Sprot
  1. Correspondence to Dr Harry Sprot, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford OX3 7LD, UK; harry.sprot{at}

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I read with interest this paper by van Spil et al1 examining further the osteoarthritis biomarker CTX-II (C-terminal telopeptide of type II collagen) and note the suspicions of the authors that this marker might be linked to bone metabolism. High correlation with biomarkers of bone and CTX-II were noted and also a characteristic increase around the time of the menopause. However, it has been …

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  • Competing interests None.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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