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Patients with rheumatoid arthritis (RA) and inflammatory polyarthritis (IP) are at increased risk of premature death, with cardiovascular disease (CVD) forming the primary cause.1–3 However, epidemiological studies have shown that traditional CVD risk factors do not fully account for the increased risk.4 ,5
We have previously reported that IP patients with baseline C reactive protein (CRP) concentrations ≥5 mg/l are at greatest risk of CVD mortality.6 Previous studies have shown that single nucleotide polymorphisms (SNPs) at the CRP gene correlate with CRP levels in a healthy population,7 and haplotypes of these SNPs are associated with CRP levels following acute coronary syndrome.8 Therefore, if CRP SNPs/haplotypes were associated with CVD in individuals with IP, it would implicate CRP in the pathogenesis of CVD (Mendelian randomisation).
The aims of this study were (1) to determine the relationship between SNP markers (rs1205, rs1800947 and rs3091244) in the CRP gene, selected …
II and DP contributed equally
Contributors AB conceived the study, designed the study, designed the data collection tools, monitored data collection, drafted and revised the manuscript. She is guarantor. II performed the genotyping, cleaned the data, performed statistical analysis, drafted and revised the manuscript. DP conceived the study, cleaned the data, performed statistical analysis, drafted and revised the manuscript. ML performed statistical analysis, drafted and revised the manuscript. SV cleaned the data, performed statistical analysis, drafted and revised the manuscript. EF performed the genotyping, drafted and revised the manuscript. DS drafted and revised the manuscript. All authors have read and approved the final manuscript for publication.
Funding Arthritis Research UK (grant reference 17552).
Competing interests None.
Ethics approval Local Hospital (Norfolk and Norwich) LREC 2003-075.
Provenance and peer review Not commissioned; externally peer reviewed.
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