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Contributors All authors were involved in drafting the article or revising it critically for important intellectual content and all authors approved the final version to be published. Study conception and design: MM, SG, ER, LI-M and MM-C. Acquisition of data: MM, SG, ER, SB-R, GL, CB, MLC and MM-C. Analysis and interpretation of data: MM, SG, ER, SB-R, GL, CB, LI-M and MM-C.
Funding This study has been supported by grants from the University of Florence (Progetti di Ricerca di Ateneo to MM-C).
Competing interests None.
Patient consent Obtained.
Ethics approval The study was approved by the institutional review board. All subjects gave written informed consent.
Provenance and peer review Not commissioned; externally peer reviewed.