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Patients with non-Jo-1 anti-RNA-synthetase autoantibodies have worse survival than Jo-1 positive patients
  1. Baptiste Hervier1,
  2. Hervé Devilliers2,
  3. Olivier Benveniste3
  1. 1Internal Medicine department 2, French Reference Centre for Lupus; Hôpital Pitié-Salpêtrière, APHP & University of Paris VI Pierre & Marie Curie, Paris, France
  2. 2Clinical Investigation Centre, Clinical Epidemiology & Clinical Trials, INSERM CIE1 and Internal Medicine & Systemic Disease Department, University Hospital of Dijon, Dijon, France
  3. 3Internal Medicine department 1, French Reference Centre for Neuromuscular Disorders; Hôpital Pitié-Salpêtrière, APHP & University of Paris VI Pierre & Marie Curie, Paris, France
  1. Correspondence to Dr Baptiste Hervier, Service de Médecine Interne 2, Centre National de référence du Lupus, 47-83 boulevard de l'hôpital, Paris, cedex 13 75651, France; bhervier{at}yahoo.fr
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http://dx.doi.org/10.1136/annrheumdis-2013-203605

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    We read with interest the manuscript by Aggarwal et al1 entitled ‘Patients with non-Jo-1 anti-RNA-synthetase autoantibodies have worse survival than Jo-1 positive patients’. This large cohort study provides important information on outcomes for patients with antisynthetase syndrome (ASS), based on the specificity of the anti-RNA-synthetase autoantibody subtypes. Interestingly, the authors decided to include patients with anti-glycyl (EJ), anti-isoleucyl (OJ) and anti-asparagyl (KS)-tRNA-synthetase autoantibodies, something which had not yet been done in the previous studies,2 ,3 due to …

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    Footnotes

    • Competing interests None.

    • Provenance and peer review Not commissioned; externally peer reviewed.

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