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Extended Report
Genetic and environmental determinants for disease risk in subsets of rheumatoid arthritis defined by the anticitrullinated protein/peptide antibody fine specificity profile
  1. Karin Lundberg1,
  2. Camilla Bengtsson2,
  3. Nastya Kharlamova1,
  4. Evan Reed1,
  5. Xia Jiang2,
  6. Henrik Kallberg3,
  7. Iskra Pollak-Dorocic1,
  8. Lena Israelsson1,
  9. Christoph Kessel4,
  10. Leonid Padyukov1,
  11. Rikard Holmdahl4,
  12. Lars Alfredsson2,
  13. Lars Klareskog1
  1. 1Department of Medicine, Karolinska Institute, Rheumatology Unit, Stockholm, Sweden
  2. 2Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden
  3. 3IMM, Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden
  4. 4Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
  1. Correspondence to Karin Lundberg, Rheumatology Unit, Department of Medicine, Karolinska Institute, Stockholm 171 76, Sweden; karin.lundberg{at}ki.se

Footnotes

  • Karin Lundberg and Camilla Bengtsson are joint first authors. Lars Alfredsson and Lars Klareskog are joint last authors.

  • Contributors KL had main responsibility for the study including design, experimental set-up, analyses, figures, supervising and writing the paper. CB had main responsibility for the statistical analyses and tables (association and interaction analyses). NK and ER performed ELISA assays, cross-reactivity experiments and produced figures with statistics. XJ produced the tables and, together with HK, contributed to the statistical analyses (association and interaction analyses). IP-D performed ELISA assays. LI set up the in-house ELISA assays. CK produced the Cit-C1 and C1 peptides. LP performed the HLA-DRB1 and PTPN22 genotyping. RH had main responsibility for the production of Cit-C1 and C1 peptides. LA supervised the statistical analyses (association and interaction analyses) and, together with LK, had main responsibility for the EIRA case-control study. LK and KL designed the study. All authors contributed to the final paper.

  • Funding The Swedish Research Council, Vinnova, the Swedish Council for Working Life and Social Research, King Gustaf V’s 80-year foundation, the Swedish Rheumatic Foundation, the EU-funded projects Gums&Joints (FP7-Health-2010-261460) and MasterSwitch (FP6-Health-2007-2.4.5-12), the IMI program BTCure (115142-2).

  • Competing interests None.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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Footnotes

  • Karin Lundberg and Camilla Bengtsson are joint first authors. Lars Alfredsson and Lars Klareskog are joint last authors.

  • Contributors KL had main responsibility for the study including design, experimental set-up, analyses, figures, supervising and writing the paper. CB had main responsibility for the statistical analyses and tables (association and interaction analyses). NK and ER performed ELISA assays, cross-reactivity experiments and produced figures with statistics. XJ produced the tables and, together with HK, contributed to the statistical analyses (association and interaction analyses). IP-D performed ELISA assays. LI set up the in-house ELISA assays. CK produced the Cit-C1 and C1 peptides. LP performed the HLA-DRB1 and PTPN22 genotyping. RH had main responsibility for the production of Cit-C1 and C1 peptides. LA supervised the statistical analyses (association and interaction analyses) and, together with LK, had main responsibility for the EIRA case-control study. LK and KL designed the study. All authors contributed to the final paper.

  • Funding The Swedish Research Council, Vinnova, the Swedish Council for Working Life and Social Research, King Gustaf V’s 80-year foundation, the Swedish Rheumatic Foundation, the EU-funded projects Gums&Joints (FP7-Health-2010-261460) and MasterSwitch (FP6-Health-2007-2.4.5-12), the IMI program BTCure (115142-2).

  • Competing interests None.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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