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Classification criteria for Sjögren's syndrome: we actually need to definitively resolve the long debate on the issue
  1. Claudio Vitali1,2,
  2. Hendrika Bootsma3,
  3. Simon J Bowman4,
  4. Thomas Dorner5,
  5. Jacques-Eric Gottenberg6,
  6. Xavier Mariette7,
  7. Manuel Ramos-Casals8,
  8. Philippe Ravaud9,
  9. Raphaele Seror7,
  10. Elke Theander10,
  11. Athanasios G Tzioufas11
  1. 1Section of Rheumatology, Casa di Cura, Lecco, Italy
  2. 2Section of Rheumatology, Istituto San Giuseppe, Anzano del Parco (Como), Italy
  3. 3Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, The Netherlands
  4. 4Rheumatology Department, University Hospital Birmingham NHS Foundation Trust, Birmingham, UK
  5. 5Department of Medicine/Rheumatology and Clinical Immunology, Charité University Hospital, Berlin, Germany
  6. 6Department of Rheumatology, Strasbourg University Hospital, Université de Strasbourg, Strasbourg, France
  7. 7Department of Rheumatology, University of Paris-Sud, AP-HP, Hôpital Bicêtre, INSERM U10102, Le Kremlin Bicêtre, France
  8. 8Laboratory of Autoimmune Diseases “Josep Font”, Hospital Clinic, Barcelona, Spain
  9. 9Center of Clinical Epidemiology, INSERM U738, Université Paris-René Descartes, Paris, France
  10. 10Department of Rheumatology, Malmö University Hospital, Lund University, Malmö, Sweden
  11. 11Department of Pathophysiology, School of Medicine, University of Athens, Athens, Greece
  1. Correspondence to Dr Claudio Vitali, via Carlo Crivelli 9 20122 Milan, Italy; c.vitali{at}


A new approach for the classification of patients with Sjögren's syndrome (SS) has been recently proposed. Although these new criteria substantially differ from the American European Consensus Group criteria, which have represented the gold standard for the last decade, when compared with each other the two sets show a high statistical degree of agreement. However, the fact that two different criteria to classify patient with SS could be available may introduce some additional difficulties in the scientific communication, making cohorts of patients selected by using different methods less than completely equivalent, and the results of epidemiological studies and therapeutic trials not entirely comparable. Consequently, to reach a consensus agreement on universally accepted classification criteria for SS seems to be a very desirable objective.

  • Sjøgren's Syndrome
  • Autoimmune Diseases
  • Outcomes research

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