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Acute calcific periarthritis is a known cause of a painful shoulder. The calcium deposits are composed of different crystalline forms, including hydroxyapatite.1 Usually, these acute episodes are self-limiting. Current treatment approaches include non-steroid anti-inflammatory drug (NSAID) and steroids.2
Microcrystals are capable of triggering interleukin (IL)-1 mediated inflammation.3 ,4 Therapeutic inhibition of IL-1 signalling has been shown to be effective in gout, and may have a place in the treatment of other crystal-induced inflammatory conditions.5 We have therefore investigated the effects of IL-1RA (anakinra) in acute calcific periarthritis in a pilot study.
Five consecutive patients (mean age of 60 years) were treated. They all had acute shoulder pain for <7 days and had not responded to 48 h …
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