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Antidrug antibodies (ADAb) to tumour necrosis factor (TNF)-specific neutralising agents in chronic inflammatory diseases: a real issue, a clinical perspective
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    Antidrug antibodies (ADAb) to tumour necrosis factor (TNF)-specific neutralizing agents in chronic inflammatory diseases: a real issue, a clinical perspective. Comment on the article of Vincent et al.
    • Alfons A den Broeder, rheumatologist-epidemiologist
    • Other Contributors:
      • Aatke van der Maas, Bart JF van den Bemt

    Dear Editor,

    Vincent et al present a thorough review of available clinical research on antidrug antibodies to tumour necrosis factor blocking agents (1). We agree to a large extent with their interpretation of the data with regard to pathofysiology, assay characteristics and variation in drug and antidrug antibody serum levels. However, the conclusion that measurement of (anti)drug levels should therefore be used f...

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