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Contributors PCEHM, JA, JS, THCMR, MHO, MJDvT, CMJvdZ, EPH, YK-K, SSMK, KD, JMvdB, MAJvR, LWAvS-S, MWS and RtC all contributed data. DMCB, CFA, LWAvS-S, PCEHM, JA, JS, TWJH, RtC, REMT and LAT contributed to the design of the study. PCEHM, JA, JS and EWNL performed tests. PCEHM, JA and JS performed analyses. PCEHM, JA, JS and LAT wrote the manuscript. All authors critically reviewed the draft manuscript and approved the version to be published.
Funding This study was also supported by the Netherlands Genomics Initiative (NGI) as part of the Netherlands Proteomics Center (NPC) and the Center for Medical Systems Biology (CMSB). LAT was financially supported by a VIDI grant from NWO-Zon-MW and a fellowship from Janssen Biologics. REMT was financially supported by a VICI grant from NWO-Zon-MW. PCEHM and The BeSt for Kids study are financially supported by Pfizer. RtC received research grants by the Dutch Arthritis Association. The ABC register is receiving unconditional support of The Board of Health Insurances (2003-2006), Pfizer (since 2007) and Abbott (since 2010). The authors wish to acknowledge the support of the European Union (FP6 integrated project Autocure, FP7 integrated project Masterswitch and IMI JU funded project BeTheCure, contract no 115142-2).
Competing interests None.
Ethics approval Institutional Review Board of Leiden University Medical Center.
Provenance and peer review Not commissioned; externally peer reviewed.
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