A multi-centre, blinded, randomised, placebo-controlled, laboratory-based study of MQX-503, a novel topical gel formulation of nitroglycerine, in patients with Raynaud phenomenon

Laura K Hummers; Carin E Dugowson; Frederick J Dechow; Robert A Wise; Jeffrey Gregory; Joel Michalek; Gayane Yenokyan; John McGready; Fredrick M Wigley

doi:10.1136/annrheumdis-2012-201536

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Clinical and epidemiological research

Extended report

A multi-centre, blinded, randomised, placebo-controlled, laboratory-based study of MQX-503, a novel topical gel formulation of nitroglycerine, in patients with Raynaud phenomenon

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	Abstract	Full	Pdf
Dec 2012	171	5	26
Jan 2013	234	12	25
Feb 2013	47	8	9
Mar 2013	30	7	6
Apr 2013	36	8	9
May 2013	30	3	6
Jun 2013	25	3	6
Jul 2013	19	5	5
Aug 2013	18	5	2
Sep 2013	47	2	5
Oct 2013	22	4	5
Nov 2013	1122	56	86
Dec 2013	356	8	31
Jan 2014	256	14	29
Feb 2014	139	16	22
Mar 2014	111	14	13
Apr 2014	68	5	5
May 2014	80	14	15
Jun 2014	52	3	5
Jul 2014	50	3	3
Aug 2014	33	5	5
Sep 2014	31	3	6
Oct 2014	48	3	6
Nov 2014	27	7	8
Dec 2014	33	3	5
Jan 2015	35	1	5
Feb 2015	55	9	7
Mar 2015	44	11	6
Apr 2015	32	0	1
May 2015	22	1	5
Jun 2015	16	1	3
Jul 2015	11	2	1
Aug 2015	16	9	6
Sep 2015	33	3	1
Oct 2015	25	3	2
Nov 2015	30	6	7
Dec 2015	31	0	1
Jan 2016	34	6	5
Feb 2016	24	3	3
Mar 2016	21	11	9
Apr 2016	27	9	6
May 2016	21	6	3
Jun 2016	20	3	0
Jul 2016	10	2	2
Aug 2016	25	9	10
Sep 2016	35	3	2
Oct 2016	23	5	3
Nov 2016	27	9	5
Dec 2016	163	2	4
Jan 2017	229	6	7
Feb 2017	150	4	4
Mar 2017	38	2	2
Apr 2017	39	2	3
May 2017	41	5	3
Jun 2017	61	9	7
Jul 2017	57	4	5
Aug 2017	83	7	6
Sep 2017	53	7	1
Oct 2017	84	5	2
Nov 2017	88	1	0
Dec 2017	74	9	7
Jan 2018	140	5	1
Feb 2018	58	5	3
Mar 2018	69	9	5
Apr 2018	67	7	4
May 2018	57	2	2
Jun 2018	44	0	0
Jul 2018	53	5	3
Aug 2018	61	4	1
Sep 2018	27	5	4
Oct 2018	75	1	1
Nov 2018	111	2	1
Dec 2018	58	3	3
Jan 2019	48	6	1
Feb 2019	36	4	1
Mar 2019	32	5	3
Apr 2019	55	1	2
May 2019	42	1	1
Jun 2019	50	0	0
Jul 2019	54	6	2
Aug 2019	38	5	1
Sep 2019	42	6	5
Oct 2019	80	3	3
Nov 2019	76	2	1
Dec 2019	115	4	2
Jan 2020	111	0	0
Feb 2020	108	4	3
Mar 2020	100	2	1
Apr 2020	71	5	3
May 2020	81	3	2
Jun 2020	86	1	2
Jul 2020	69	2	2
Aug 2020	64	1	0
Sep 2020	102	1	5
Oct 2020	80	0	1
Nov 2020	135	1	0
Dec 2020	111	0	0
Jan 2021	112	3	3
Feb 2021	148	3	3
Mar 2021	141	2	3
Apr 2021	62	0	0
May 2021	32	2	4
Jul 2021	1	0	0
Aug 2021	5	4	2
Sep 2021	1	1	1
Oct 2021	105	6	5
Nov 2021	108	0	1
Dec 2021	145	0	0
Jan 2022	180	1	1
Feb 2022	165	3	3
Mar 2022	105	1	0
Apr 2022	97	1	1
May 2022	154	2	8
Jun 2022	133	2	1
Jul 2022	104	2	1
Aug 2022	96	4	0
Sep 2022	98	4	0
Oct 2022	102	4	2
Nov 2022	73	0	0
Dec 2022	70	1	1
Jan 2023	76	5	6
Feb 2023	100	4	2
Mar 2023	35	1	1
Apr 2023	37	0	0
May 2023	77	1	1
Jun 2023	46	0	0
Jul 2023	42	1	1
Aug 2023	35	1	0
Sep 2023	41	1	0
Oct 2023	33	0	0
Nov 2023	48	0	0
Dec 2023	81	1	1
Jan 2024	78	3	3
Feb 2024	129	1	1
Mar 2024	47	3	2
Total	10610	570	614

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