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Which B-cell subset should we target in lupus?
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  • Published on:
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    Dear Editor,

    We thank Aramugakani et al. for their critical reading of our Editorial (1) accompanying Cheng et al. paper on the role of long-lived plasma cells (PC) in driving murine lupus nephritis (LN) (2). First, we obviously share - and explicitely mentioned - the safety issues related to long-lived PC depletion, in particular a possible high infection rate. Second, our purpose was not to question the effe...

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    Conflict of Interest:
    None declared.
  • Published on:
    Reply to: Which B-cell subset should we target in lupus?
    • Gururaj Arumugakani, Clinical Research Fellow
    • Other Contributors:
      • Dr.Edward Vital, Dr.Yuzaiful Yusof, Prof.Dennis McGonagle, Prof.Paul Emery

    Dear Editor,

    We read with interest the editorial by Ferraccioli and Houssiau proposing the specific targeting of long lived plasma cells (PCs) in human lupus nephritis (LN) [1]. The authors present a cogent summary of experiments showing that long-lived PCs alone are sufficient to induce murine LN, and that targeting of PCs in these models is successful. However, we believe that clinical experience with the treatme...

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    Conflict of Interest:
    None declared.