Adding tocilizumab or switching to tocilizumab monotherapy in methotrexate inadequate responders: 24-week symptomatic and structural results of a 2-year randomised controlled strategy trial in rheumatoid arthritis (ACT-RAY)

Maxime Dougados; Karsten Kissel; Tom Sheeran; Paul P Tak; Philip G Conaghan; Emilio Martín Mola; Georg Schett; Howard Amital; Federico Navarro-Sarabia; Antony Hou; Corrado Bernasconi; TWJ Huizinga

doi:10.1136/annrheumdis-2011-201282

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Clinical and epidemiological research

Adding tocilizumab or switching to tocilizumab monotherapy in methotrexate inadequate responders: 24-week symptomatic and structural results of a 2-year randomised controlled strategy trial in rheumatoid arthritis (ACT-RAY)

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	Abstract	Full	Pdf
May 2012	475	378	501
Jun 2012	235	269	279
Jul 2012	788	279	369
Aug 2012	317	200	206
Sep 2012	292	161	155
Oct 2012	245	176	164
Nov 2012	177	157	133
Dec 2012	1734	245	298
Jan 2013	1090	313	276
Feb 2013	619	196	257
Mar 2013	445	133	153
Apr 2013	309	77	138
May 2013	316	119	159
Jun 2013	172	60	77
Jul 2013	165	66	81
Aug 2013	156	65	66
Sep 2013	163	101	102
Oct 2013	162	102	91
Nov 2013	144	99	98
Dec 2013	137	63	60
Jan 2014	146	60	77
Feb 2014	145	122	105
Mar 2014	164	78	82
Apr 2014	169	96	88
May 2014	157	82	73
Jun 2014	127	70	81
Jul 2014	158	116	58
Aug 2014	113	110	64
Sep 2014	115	87	55
Oct 2014	120	122	65
Nov 2014	68	67	45
Dec 2014	88	47	39
Jan 2015	93	76	59
Feb 2015	86	62	47
Mar 2015	120	69	54
Apr 2015	72	63	36
May 2015	74	63	43
Jun 2015	60	45	51
Jul 2015	100	81	45
Aug 2015	79	60	46
Sep 2015	103	64	51
Oct 2015	79	49	32
Nov 2015	100	59	53
Dec 2015	86	79	62
Jan 2016	66	77	46
Feb 2016	65	52	31
Mar 2016	58	65	48
Apr 2016	77	69	33
May 2016	54	63	23
Jun 2016	54	51	36
Jul 2016	74	48	36
Aug 2016	71	63	55
Sep 2016	76	66	43
Oct 2016	69	63	44
Nov 2016	113	35	43
Dec 2016	72	35	34
Jan 2017	57	30	27
Feb 2017	41	46	53
Mar 2017	25	63	50
Apr 2017	15	70	34
May 2017	14	76	22
Jun 2017	39	93	37
Jul 2017	112	105	28
Aug 2017	129	103	43
Sep 2017	133	92	30
Oct 2017	154	116	31
Nov 2017	136	108	51
Dec 2017	334	306	30
Jan 2018	251	227	48
Feb 2018	162	118	19
Mar 2018	160	144	31
Apr 2018	238	202	54
May 2018	179	155	43
Jun 2018	128	116	31
Jul 2018	113	99	32
Aug 2018	144	134	32
Sep 2018	109	87	19
Oct 2018	179	167	24
Nov 2018	194	176	17
Dec 2018	170	148	18
Jan 2019	151	127	18
Feb 2019	89	82	12
Mar 2019	110	70	44
Apr 2019	60	30	17
May 2019	76	48	30
Jun 2019	55	43	23
Jul 2019	72	45	31
Aug 2019	68	40	36
Sep 2019	47	35	20
Oct 2019	65	52	31
Nov 2019	43	28	25
Dec 2019	54	34	27
Jan 2020	47	35	24
Feb 2020	65	48	12
Mar 2020	61	43	26
Apr 2020	69	53	11
May 2020	84	78	43
Jun 2020	38	35	25
Jul 2020	50	36	27
Aug 2020	30	28	19
Sep 2020	59	52	21
Oct 2020	62	40	28
Nov 2020	72	58	17
Dec 2020	58	44	17
Jan 2021	48	48	21
Feb 2021	87	32	26
Mar 2021	89	72	29
Apr 2021	52	48	17
May 2021	40	34	14
Jun 2021	37	37	20
Jul 2021	47	47	32
Aug 2021	36	36	27
Sep 2021	46	46	18
Oct 2021	83	72	40
Nov 2021	68	48	41
Dec 2021	41	30	15
Jan 2022	53	35	12
Feb 2022	41	39	16
Mar 2022	68	62	18
Apr 2022	110	66	18
May 2022	61	59	33
Jun 2022	77	72	32
Jul 2022	64	53	26
Aug 2022	75	65	31
Sep 2022	87	73	29
Oct 2022	77	52	26
Nov 2022	85	71	10
Dec 2022	75	62	12
Jan 2023	119	109	16
Feb 2023	126	107	19
Mar 2023	86	70	16
Apr 2023	65	51	13
May 2023	92	82	25
Jun 2023	55	41	6
Jul 2023	51	44	20
Aug 2023	71	55	41
Sep 2023	106	97	19
Oct 2023	284	268	15
Nov 2023	346	337	15
Dec 2023	250	210	25
Jan 2024	155	119	34
Feb 2024	119	79	18
Mar 2024	76	76	21
Total	19961	12942	7800

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