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AB0820 Physical disability in mixed connective tissue disease
  1. M. Olesinska1,
  2. Z. Czuszynska2,
  3. A. Felis-Giemza1,
  4. K. Walkiewicz-Pielaszek1,
  5. A. Paradowska-Gorycka3,
  6. L. Rutkowska-Sak4,
  7. I. Szczygielska4,
  8. E. Wiesik-Szewczyk1,
  9. Z. Zdrojewski2
  1. 1Department of Connective Tissue Diseases, Institute of Rheumatology, Warsaw
  2. 2Department of Internal Medicine, Connective Tissue Diseases and Geriatric, Medical University, Gdansk
  3. 3Department of Biochemistry
  4. 4Department of Pediatric Rheumatology, Institute of Rheumatology, Warsaw, Poland


Background Diminished physical disability is cause of morbidity in rheumatic diseases. It is well recognized problem in RA, however not yet systematically assessed in MCTD.

Objectives To evaluate physical disability and its connections with clinical variables in patients with MCTD.

Methods The wide range of clinical assessment of 69 MCTD patients (pts) was performed. Diagnosis was made based on Kasukawa criteria. Evaluation of physical disability was measured by HAQ-DI. Its correlations with demographic and clinical variables (clinical and serological features, Body Mass Index (BMI), treatment, disease activity, disease damage) by Spearman’s rank correlation were analyzed. Disease activity was assessed independently at the same time by patient (VASPtA) and physician (VASdrA) with 100 mm visual analogue scale. The same method was used to assess disease damage: VASptD and VASdrD, respectively as well objective method Damage Index (DI) was prepared for MCTD (based on SLICC/ACR DI). Study was accepted by Local Ethics Committee.

Results Median of MCTD pts age was 45 years (16 - 66), median of disease duration: 117,8 months (10-420). Median of HAQ-DI was 1.4 (min 0-max 2.25). No limitation of physical function (HAQ-DI=0) reported 17 pts (25%), mild to medium limitation (HAQ-DI: 0.1-1.0) – 41 pts (59,4%) and medium to severe limitation (HAQ-DI >1,1) – 11 pts (15,9%). HAQ-DI correlated well with disease activity and damage assessed by patient: VASptA: R=0,524; p<0,001; VASptD: R=0,527; p<0,001 and disease damage by DI: R=0,400; p<0,001. Weak correlation HAQ-DI with doctor’s assessment was observed: VASdrA: R=0,243; p=0,045, VASdrD: R=0,284; p=0,019. Among analyzed clinical data statistically significant correlations were found for BMI (R=0,262; P=0,03), patient age (R=0,259; P=0,033).

Conclusions Our data suggest that the physical disability is an important factor describing health status in MCTD patients. In the study, similarly like it was proved in RA [1], correlations of disability and both disease activity and irreversible damage were observed.

  1. Aletaha D2006; 54: 2784–92.

Disclosure of Interest None Declared

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