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Alcohol consumption protects against arthritis development in seropositive arthralgia patients
  1. Lotte A van de Stadt1,
  2. Dirkjan van Schaardenburg1,2
  1. 1Jan van Breemen Research Institute/Reade, Amsterdam, The Netherlands
  2. 2Department of Rheumatology, VU University Medical Center, Amsterdam, The Netherlands
  1. Correspondence to Lotte A van de Stadt, Jan van Breemen Research Institute Reade, Dr Jan van Breemenstraat 2, 1056AB Amsterdam, The Netherlands; l.vd.stadt{at}

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Patients with arthralgia and auto-antibodies such as anticitrullinated protein antibodies and/or IgM-rheumatoid factor (seropositive) are at risk for developing rheumatoid arthritis (RA).1 RA is associated with lower alcohol intake, suggesting that alcohol consumption is protective for the development of RA.2,,5 The proposed mechanism for this effect is that alcohol is immunosuppressive, possibly via intrinsic corticosteroid production. In animal …

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  • Funding The Dutch Arthritis Association.

  • Competing interests None.

  • Ethics approval Approval provided by the Ethics Committee of Reade and Slotervaart hospital, Amsterdam, The Netherlands.

  • Provenance and peer review Not commissioned; externally peer reviewed.