Comparative effectiveness and safety of biological treatment options after tumour necrosis factor α inhibitor failure in rheumatoid arthritis: systematic review and indirect pairwise meta-analysis

Monika Schoels; Daniel Aletaha; Josef S Smolen; John B Wong

doi:10.1136/annrheumdis-2011-200490

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Clinical and epidemiological research

Extended report

Comparative effectiveness and safety of biological treatment options after tumour necrosis factor α inhibitor failure in rheumatoid arthritis: systematic review and indirect pairwise meta-analysis

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	Abstract	Full	Pdf
Jan 2012	71	6	25
Feb 2012	320	193	318
Mar 2012	194	132	151
Apr 2012	122	68	80
May 2012	108	79	79
Jun 2012	75	37	42
Jul 2012	1328	86	294
Aug 2012	656	63	180
Sep 2012	464	109	125
Oct 2012	357	87	153
Nov 2012	174	86	76
Dec 2012	192	54	75
Jan 2013	160	37	62
Feb 2013	128	45	60
Mar 2013	153	36	68
Apr 2013	110	41	55
May 2013	126	39	64
Jun 2013	66	30	36
Jul 2013	72	25	30
Aug 2013	78	29	39
Sep 2013	48	21	25
Oct 2013	59	32	36
Nov 2013	68	29	27
Dec 2013	42	20	18
Jan 2014	63	24	25
Feb 2014	66	27	39
Mar 2014	51	16	15
Apr 2014	73	16	23
May 2014	76	34	39
Jun 2014	36	15	17
Jul 2014	59	15	19
Aug 2014	41	20	18
Sep 2014	60	17	23
Oct 2014	58	23	27
Nov 2014	70	14	16
Dec 2014	41	14	14
Jan 2015	54	28	24
Feb 2015	44	16	17
Mar 2015	75	23	26
Apr 2015	32	18	9
May 2015	67	5	8
Jun 2015	41	12	14
Jul 2015	55	6	15
Aug 2015	40	9	13
Sep 2015	61	18	20
Oct 2015	24	7	8
Nov 2015	32	9	10
Dec 2015	68	7	9
Jan 2016	138	17	30
Feb 2016	48	14	14
Mar 2016	30	22	22
Apr 2016	34	11	14
May 2016	23	13	13
Jun 2016	22	9	6
Jul 2016	33	8	6
Aug 2016	41	13	14
Sep 2016	54	14	21
Oct 2016	31	6	6
Nov 2016	89	18	21
Dec 2016	29	13	10
Jan 2017	37	17	14
Feb 2017	54	8	11
Mar 2017	49	18	15
Apr 2017	72	19	11
May 2017	66	40	24
Jun 2017	97	14	13
Jul 2017	131	29	14
Aug 2017	131	19	14
Sep 2017	179	22	12
Oct 2017	155	17	11
Nov 2017	128	12	7
Dec 2017	101	20	9
Jan 2018	161	31	15
Feb 2018	120	23	10
Mar 2018	144	28	14
Apr 2018	119	18	10
May 2018	118	23	19
Jun 2018	75	11	3
Jul 2018	77	10	4
Aug 2018	78	11	3
Sep 2018	80	4	2
Oct 2018	92	11	8
Nov 2018	70	3	2
Dec 2018	71	3	0
Jan 2019	359	35	5
Feb 2019	54	6	5
Mar 2019	95	11	11
Apr 2019	90	14	12
May 2019	88	5	3
Jun 2019	51	9	5
Jul 2019	66	12	7
Aug 2019	56	6	4
Sep 2019	73	7	10
Oct 2019	121	19	13
Nov 2019	90	7	4
Dec 2019	84	5	4
Jan 2020	68	6	2
Feb 2020	121	36	2
Mar 2020	44	12	2
Apr 2020	51	9	2
May 2020	71	5	1
Jun 2020	95	4	4
Jul 2020	65	10	2
Aug 2020	74	13	2
Sep 2020	99	5	3
Oct 2020	54	8	3
Nov 2020	83	12	4
Dec 2020	47	6	3
Jan 2021	52	8	5
Feb 2021	91	8	4
Mar 2021	107	15	7
Total	11784	2639	3117

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