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Susceptibility genes to systemic sclerosis (SSc) are substantially shared by other autoimmune diseases.1 UBE2L3, encoding a ubiquitin-conjugating enzyme, was associated with systemic lupus erythematosus (SLE)2 3 and rheumatoid arthritis (RA).4 In this study, we examined whether UBE2L3 is associated with SSc.
A case–control association study was performed on 391 Japanese patients and 1010 healthy controls recruited at Kanazawa University, the University of Tokyo, Institute of Rheumatology, Tokyo Women's Medical University and Sagamihara Hospital, National Hospital Organisation. All patients and …
Funding This work was supported by grant-in-aid for scientific research (B) (22390199) and grant-in-aid for young scientists (B) (23791101) from the Japan Society for the Promotion of Science, Health and Labour Science Research Grants for research on intractable diseases from the Ministry of Health, Labour and Welfare of Japan, Takeda Science Foundation and Japan Allergy Foundation.
Competing interests None.
Ethics approval The study was conducted with the approval of the ethics committees at University of Tsukuba, Tokyo Women's Medical University, National Hospital Organisation Sagamihara Hospital and the University of Tokyo.
Provenance and peer review Not commissioned; externally peer reviewed.
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