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Association of UBE2L3 polymorphisms with diffuse cutaneous systemic sclerosis in a Japanese population
  1. Narumi Hasebe1,
  2. Aya Kawasaki1,
  3. Ikue Ito1,
  4. Manabu Kawamoto2,
  5. Minoru Hasegawa3,
  6. Manabu Fujimoto3,
  7. Hiroshi Furukawa4,
  8. Shigeto Tohma4,
  9. Takayuki Sumida5,
  10. Kazuhiko Takehara3,
  11. Shinichi Sato6,
  12. Yasushi Kawaguchi2,
  13. Naoyuki Tsuchiya1
  1. 1Molecular and Genetic Epidemiology Laboratory, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
  2. 2Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan
  3. 3Department of Dermatology, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
  4. 4Clinical Research Centre for Allergy and Rheumatology, Sagamihara Hospital, National Hospital Organisation, Sagamihara, Japan
  5. 5Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
  6. 6Department of Dermatology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
  1. Correspondence to Dr Naoyuki Tsuchiya, Molecular and Genetic Epidemiology Laboratory, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan; tsuchiya-tky{at}

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Susceptibility genes to systemic sclerosis (SSc) are substantially shared by other autoimmune diseases.1 UBE2L3, encoding a ubiquitin-conjugating enzyme, was associated with systemic lupus erythematosus (SLE)2 3 and rheumatoid arthritis (RA).4 In this study, we examined whether UBE2L3 is associated with SSc.

A case–control association study was performed on 391 Japanese patients and 1010 healthy controls recruited at Kanazawa University, the University of Tokyo, Institute of Rheumatology, Tokyo Women's Medical University and Sagamihara Hospital, National Hospital Organisation. All patients and …

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  • Funding This work was supported by grant-in-aid for scientific research (B) (22390199) and grant-in-aid for young scientists (B) (23791101) from the Japan Society for the Promotion of Science, Health and Labour Science Research Grants for research on intractable diseases from the Ministry of Health, Labour and Welfare of Japan, Takeda Science Foundation and Japan Allergy Foundation.

  • Competing interests None.

  • Ethics approval The study was conducted with the approval of the ethics committees at University of Tsukuba, Tokyo Women's Medical University, National Hospital Organisation Sagamihara Hospital and the University of Tokyo.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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