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Reduced vitamin D levels are associated with autoimmune response in tuberculosis patients
  1. Wenli Li1,2,
  2. Rui Zhang1,
  3. Kuo Zhang1,
  4. Liqiong Song1,2,
  5. Ping H Hong1,2,
  6. Yuan Zhang1,2,
  7. Jiehong Xie1,
  8. Lunan Wang1,
  9. Jinming Li1
  1. 1National Center for Clinical Laboratories, Beijing Hospital, Beijing, People's Republic of China
  2. 2Graduate School, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, People's Republic of China
  1. Correspondence to Dr Jinming Li, National Center for Clinical Laboratories, Beijing Hospital, Department of Immunoassay and Molecular Diagnosis, Beijing 100730, China; ljm63hn{at}yahoo.com.cn
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http://dx.doi.org/10.1136/annrheumdis-2011-201127

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    A recent report found that vitamin D deficiency was associated with an increased autoimmune response in healthy individuals and systemic lupus erythematosus patients.In addition, a potential mechanism about the role of vitamin D in B cell hyperactivity and autoantibody production had been proposed.1 However, increased autoimmune response and autoantibody production can also be observed in several other diseases such as tuberculosis (TB). Accumulating evidences demonstrate that TB patients have high titres of a variety of autoantibodies.2,–,4 Our research sought to investigate whether a …

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    Footnotes

    • Funding The study was supported by the National High-Technology Research and Development Program of China (863 Program).

    • Competing interests None.

    • Patient consent Obtained.

    • Ethics approval The study was approved by the ethics committee of the National Center for Clinical Laboratories.

    • Provenance and peer review Not commissioned; externally peer reviewed.

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