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High level of functional dickkopf-1 predicts protection from syndesmophyte formation in patients with ankylosing spondylitis
  1. Gisela Ruiz Heiland1,
  2. Heiner Appel2,
  3. Denis Poddubnyy2,
  4. Jochen Zwerina1,
  5. Axel Hueber1,
  6. Hildrun Haibel2,
  7. Xenofon Baraliakos3,
  8. Joachim Listing4,
  9. Martin Rudwaleit2,
  10. Georg Schett1,
  11. Joachim Sieper2,4
  1. 1Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen–Nuremberg, Erlangen, Germany
  2. 2Medical Department I, Rheumatology, Charité, Campus Benjamin Franklin, Berlin, Germany
  3. 3Rheumatism Centre, Region of Ruhr, Herne, Germany
  4. 4Department of Epidemiology, German Rheumatism Research Centre, Berlin, Germany
  1. Correspondence to Georg Schett, Department of Rheumatology, University of Erlangen–Nuremberg, Krankenhausstrasse 12, D-91054 Erlangen, Germany; georg.schett{at}uk-erlangen.de

Footnotes

  • Funding This study was supported by the Deutsche Forschungsgemeinschaft (SPP1468-IMMUNOBONE), the Bundesministerium für Bildung und Forschung (BMBF; projects ANCYLOSS and Competence Network Rheumatology), the MASTERSWITCH and BTCure projects of the European Union, the Interdisciplinary Centre for Clinical Research and the ELAN fund of the University of Erlangen-Nuremberg.

  • Competing interests None.

  • Ethics approval The GESPIC study was approved by the medical ethics committees of all participating centres.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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Footnotes

  • Funding This study was supported by the Deutsche Forschungsgemeinschaft (SPP1468-IMMUNOBONE), the Bundesministerium für Bildung und Forschung (BMBF; projects ANCYLOSS and Competence Network Rheumatology), the MASTERSWITCH and BTCure projects of the European Union, the Interdisciplinary Centre for Clinical Research and the ELAN fund of the University of Erlangen-Nuremberg.

  • Competing interests None.

  • Ethics approval The GESPIC study was approved by the medical ethics committees of all participating centres.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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