Article Text

Reversible male infertility under treatment with an anti-TNFα agent: a case report
  1. Lukas M Wildi,
  2. Boulos Haraoui
  1. Department of Rheumatology, University of Montreal Hospital Centre (CHUM), Montreal, Quebec, Canada
  1. Correspondence to Lukas M Wildi, Department of Rheumatology, University of Montreal Hospital Centre (CHUM), Notre-Dame Hospital, 1560, Sherbrooke Street East, Montreal, QC H2L 4M1, Canada; lukas.wildi{at}

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More than a decade of use of the anti-tumour necrosis factor (anti-TNF) agents in rheumatology has confirmed their acceptable safety profile and very few new rare side effects have emerged. However, TNFα, a pleiotropic cytokine, is important to many physiological functions and its suppression may lead to unexpected consequences. We describe here a rare case of reversible oligoasthenozoospermia in a young patient.

Case report

This case concerns a 35-year-old father of a healthy 4-year-old child who was successfully treated for 3 years with adalimumab, a monoclonal human antibody against TNFα, 40 mg subcutaneously every 2 weeks for ankylosing spondylitis (AS). The therapy …

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