Article Text

Download PDFPDF
Association study of BAK1 gene polymorphisms in Spanish rheumatoid arthritis and systemic lupus erythematosus cohorts
  1. Lina-Marcela Díaz-Gallo1,
  2. Sonia Garcia1,
  3. Norberto Ortego-Centeno2,
  4. Juan Jiménez-Alonso3,
  5. Julio Sánchez-Román4,
  6. Enrique de Ramón5,
  7. María F González-Escribano6,
  8. Alejandro Balsa7,
  9. Benjamín Fernández-Gutierrez8,
  10. Isidoro González-Alvaro9,
  11. Miguel A González-Gay10,
  12. Javier Martin1
  1. 1Cellular Biology and Immunology Department, Instituto de Parasitología y Biomedicina ‘López-Neyra’, CSIC (IPBLN-CSIC), Granada, Spain
  2. 2Servicio de Medicina Interna, Hospital Clínico San Cecilio, Granada, Spain
  3. 3Servicio de Medicina Interna, Hospital Virgen de las Nieves, Granada, Spain
  4. 4Servicio de Medicina Interna, Hospital Virgen del Rocío, Sevilla, Spain
  5. 5Servicio de Medicina Interna, Hospital Carlos Haya, Málaga, Spain
  6. 6Servicio de Inmunología, Hospital Virgen del Rocío, Sevilla, Spain
  7. 7Servicio de Reumatología, Hospital Universitario La Paz, Madrid, Spain
  8. 8Servicio de Reumatología, Hospital Clínico San Carlos, Madrid, Spain
  9. 9Servicio de Reumatología, Hospital Universitario La Princesa, IIS-Princesa, Madrid, Spain
  10. 10Servicio de Reumatología, IFIMAV, Hospital Universitario Marqués de Valdecilla, Santander, Spain
  1. Correspondence to Lina-Marcela Díaz-Gallo, Cellular Biology and Immunology Department, Instituto de Parasitología y Biomedicina ‘López-Neyra’, IPBLN-CSIC, Parque Tecnológico de Ciencias de la Salud, Avenida del Conocimiento S/N, 18100-Armilla (Granada), Spain; lina.diaz{at}

Statistics from

Cumulative evidence indicates that the BCL2-antagonist/killer 1 (BAK1) gene could be involved in several autoimmune diseases.1 2 The proapoptotic BCL2 family members BAX and BAK are essential for regulating the number of B and T cells.2,,4 A recent study in a Colombian population suggested that the BAK1 rs513349 and rs5745582 single nucleotide polymorphisms (SNPs) as well as the haplotype rs513349G-rs561276C-rs5745582A are significantly associated with autoimmune rheumatic diseases.1 The aim of the present study was to evaluate the influence …

View Full Text


  • Funding This work was partially supported by RETICS Program, RD08/0075 (RIER) from Instituto de Salud Carlos III (ISCIII), within the VI PN de I+D+i 2008–2011 (FEDER). L-MD-G was supported by the ‘Ayudas Predoctorales de Formación en Investigación en Salud (PFIS—FI09/00544)’ from the ‘Instituto de Salud Carlos III’.

  • Competing interests None.

  • Ethics approval The study was approved by the local ethical committees of all participating centres.

  • Provenance and peer review Not commissioned; externally peer reviewed.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.