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Psoriatic arthritis (PsA) is characterised by joint inflammation in patients with psoriasis or a family history of psoriasis. A study of the Icelandic genealogical database supports a strong genetic component with a 40-fold increased risk of disease in first-degree relatives of patients with PsA.1 In order to identify genes that predispose to disease, two study designs have become prominent in recent years: the candidate gene and the genome-wide association (GWA) approach, using case-control cohorts.
Although GWA studies allow a comprehensive analysis of the genome for susceptibility variants, they remain expensive and only three GWAs in PsA have been published to date.2,–,4 These have identified the HLA C, IL23R, IL12B, IL13 and TRAF3IP2 genes as being robustly associated with PsA. Due to issues of multiple testing, only those loci that reach stringent significance thresholds can claim to show confirmed association with PsA. …
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