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Reply to: Subclinical renal dysfunction is independently associated with cardiovascular events in rheumatoid arthritis: the CARRÉ Study
  1. Tomoyuki Kawada
  1. Correspondence to Dr Tomoyuki Kawada, Department of Hygiene and Public Health, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 1138602, Japan; kawada{at}

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I read with great interest the paper by van Sijl et al,1 a 3-year longitudinal study by following patients with rheumatoid arthritis (RA) to know the effect of the estimated renal function on cardiovascular (CV) events. Out of 330 participants, 23 had a CV event (7%). They mentioned the study limitation of low statistical power derived from the small number of CV events, and the restriction of confounding variables for the analysis. This limitation reflects on the number of independent variables in their study presented in Table 2. Furthermore, …

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  • Competing interests None.

  • Provenance and peer review Not commissioned; internally peer reviewed.