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We recently published a meta-analysis of malignancy rates reported from prospective observational studies in patients treated with tumour necrosis factor inhibitors (TNF-I).1 While there was no increase in the rates of all-site malignancy or lymphoma, there was an increased risk of non-melanoma skin cancer (NMSC) (1.45, 95% CI 1.15 to 1.76).
The skin cancer analysis included data from an abstract from the British Society for Rheumatology Biologics Register (BSRBR)2 that has since been published as a full paper with different …
Competing interests XM has received research grants or honoraria from Bristol Myers Squibb, GSK, Pfizer and Roche; AR was an employee of Wyeth Europa and had held shares in Wyeth and currently has Pfizer share options, and has undertaken consultancy work for UCB Pharma and Pfizer; PE has received research grants or honoraria from Bristol Myers Squibb, GSK, Pfizer and Roche. This work was undertaken without external funding.
Provenance and peer review Not commissioned; internally peer reviewed.
Xavier Mariette, Marco Matucci-Cerinic, Karel Pavelka, Peter Taylor, Ronald van Vollenhoven, Rebecca Heatley, Claire Walsh, Richard Lawson, Alan Vaughan Reynolds, Paul Emery
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