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Immunogenicity of adalimumab could impair important treatment outcome parameters in patients with rheumatoid arthritis (RA). Patients who developed antiadalimumab antibodies (AAA) during a 3 year time period achieved less often minimal disease activity or remission and treatment failure occurred more often compared with patients without AAA.1 There were remarkable baseline differences: patients developing AAA had more long-standing, severe disease and less often used concomitant medication including lower doses of methotrexate (MTX), compared with patients not developing AAA. In literature, a favourable effect of concomitant MTX use on the immunogenicity of adalimumab for several inflammatory conditions is suggested.2
To investigate which MTX dose is sufficient to reduce immunogenicity, patients of …
Footnotes
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Funding Funding was provided by Abbott Laboratories and Pfizer. Abbott Laboratories and Pfizer had no involvement in the study design; in the collection, analysis and interpretation of data; in the writing of the manuscript; or in the decision to submit the manuscript for publication. In addition, this investigation was also facilitated by the Division of Research & Education of the Jan van Breemen Research Institute | Reade.
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Competing interests CLK declares no competing interest. MTN has received consultancy fees from Abbott, Roche, Pfizer, Merk Sharp and Dohme (MSD), Union chimique belge (UCB), Swedisch orphan biovitrum (sobi) Bristol-Myers Squibb (BMS), payment for lectures from Abbott, Roche and Pfizer. GJW has received a research grant from Pfizer (Wyeth) (paid to the Institution) and payments for lectures from Pfizer and Amgen.
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Ethics approval The study was approved by the medical ethics committee of Reade and Slotervaart Ziekenhuis.
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Provenance and peer review Not commissioned; externally peer reviewed.