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Methotrexate reduces immunogenicity in adalimumab treated rheumatoid arthritis patients in a dose dependent manner

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  • Funding Funding was provided by Abbott Laboratories and Pfizer. Abbott Laboratories and Pfizer had no involvement in the study design; in the collection, analysis and interpretation of data; in the writing of the manuscript; or in the decision to submit the manuscript for publication. In addition, this investigation was also facilitated by the Division of Research & Education of the Jan van Breemen Research Institute | Reade.

  • Competing interests CLK declares no competing interest. MTN has received consultancy fees from Abbott, Roche, Pfizer, Merk Sharp and Dohme (MSD), Union chimique belge (UCB), Swedisch orphan biovitrum (sobi) Bristol-Myers Squibb (BMS), payment for lectures from Abbott, Roche and Pfizer. GJW has received a research grant from Pfizer (Wyeth) (paid to the Institution) and payments for lectures from Pfizer and Amgen.

  • Ethics approval The study was approved by the medical ethics committee of Reade and Slotervaart Ziekenhuis.

  • Provenance and peer review Not commissioned; externally peer reviewed.