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Leptin is a hormone originally discovered in white adipocytes which regulates energy metabolism and appetite. Obese individuals have increased levels of circulating leptin, as compared with their non-obese counterparts, and in mouse models, leptin deficiency causes morbid obesity.1 However, due to the appearance of leptin resistance in the hypothalamus, increased blood levels of leptin in obese subjects fail to induce the expected responses to high leptin, that is, increased energy expenditure, reduced food intake and decreased body weight.2 Leptin resistance has been shown to be mediated by an increased expression of the suppressor of cytokine signalling-3 (SOCS-3).1 ,2
Obesity has been thought to contribute to the development of osteoarthritis (OA) by increasing the load on weight-bearing joints. However, this appears to be an over-simplification, since obesity is also linked to …
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