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Immunoglobulin (Ig)G4-related disease (IgG4-RD) is a chronic inflammatory disorder characterised by elevated levels of serum IgG4 and swollen organs with fibrosis and infiltration by abundant IgG4-positive plasmacytes.1 ,2 Glucocorticoid treatment is effective for achieving clinical remission in the short term,3 but about 20%–30% of cases present with relapse after steroid doses are reduced.4 Serial changes of serum IgG4 levels are often considered to reflect the disease activity in routine clinical practice,5 but how disease relapse occurs is not well understood. We therefore analysed relapse patterns in IgG4-RD on the basis of data from the Sapporo Medical university And …
Competing interests None.
Patient consent Obtained.
Ethics approval Written consent to use the information from these cases was obtained from the patients in accordance with the Declaration of Helsinki. This study proceeded under the approval of our institutional IRB (SMU 22-57).
Provenance and peer review Not commissioned; externally peer reviewed.
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