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The IL-23R region is associated with a number of non-infectious inflammatory conditions including inflammatory bowel disease, ankylosing spondylitis and psoriasis,1,–,3 and albeit with less consistent evidence, rheumatoid arthritis (RA).4,–,6 Association of rs1343151 (G→A) with RA, but not rs1004819/rs10489629/rs2201841, has been reported in European and New Zealand sample sets;5 none of rs3212227/rs6887695/rs7530511 was associated in European and North American sample sets,6 and rs7517847 was not associated in meta-analysed European and New Zealand sample sets.4 Given the immunological evidence pointing to the importance of the Th17–IL-23 axis in inflammation and autoimmunity,7 and the unresolved question of whether or not IL-23R is associated with RA, we further investigated association of IL-23R with RA in white European Caucasian case–control sample sets (cases ascertained …
Funding The study was funded by Health Research Council of New Zealand.
Competing interests None.
Ethics approval The study was approved by the Madrid and Lugo hospital ethics committees, The Regional Committees for Research Ethics in Eastern and Southern Norway, Multi-region Ethics Committee and the Lower South Ethics Committee of New Zealand, the Lewisham Hospital and Guy's and St Thomas' Hospitals local research ethics committees, The Oxford Research Ethics Committee.
Provenance and peer review Not commissioned; externally peer reviewed.