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Radiographic improvement of damaged large joints in children with systemic juvenile idiopathic arthritis following tocilizumab treatment
  1. Yutaka Inaba1,
  2. Remi Ozawa2,
  3. Tomoyuki Imagawa2,
  4. Masaaki Mori2,
  5. Yoshinori Hara2,
  6. Takako Miyamae2,
  7. Chie Aoki1,
  8. Tomoyuki Saito1,
  9. Shumpei Yokota2
  1. 1Department of Orthopaedic Surgery, Yokohama City University, Yokohama, Japan
  2. 2Department of Pediatrics, Yokohama City University, Yokohama, Japan
  1. Correspondence to Yutaka Inaba, Department of Orthopaedic Surgery, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan; yute0131{at}

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Very few studies have reported radiographic improvement of damaged joints in patients with juvenile idiopathic arthritis (JIA) following treatment with biological response modifiers.1 We previously reported the efficacy and safety of tocilizumab, an anti-interleukin 6 receptor monoclonal antibody, in patients with systemic-onset JIA.2,,4 In the present study, we investigated remodelling characteristics of damaged large joints, especially weight-bearing joints, by radiographic examination following tocilizumab treatment for 5 years.

Seven patients (two female and five male) with systemic-onset JIA, receiving 8 mg/kg of tocilizumab intravenously every 2 weeks, were …

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  • Competing interests None.

  • Patient consent Obtained.

  • Ethics approval All participants provided written informed consent, and this study was approved by the Institutional Review Board of Yokohama City University, Yokohama, Japan.

  • Provenance and peer review Not commissioned; externally peer reviewed.