Article Text

Download PDFPDF

Bone mineral density and joint cartilage: four clinical settings of a complex relationship in osteoarthritis
  1. Gabriel Herrero-Beaumont1,
  2. Jorge A Roman-Blas1,
  3. Raquel Largo1,
  4. Francis Berenbaum2,
  5. Santos Castañeda3
  1. 1Bone and Joint Research Unit, Service of Rheumatology, IIS-Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain
  2. 2Pierre and Marie Curie University, Department of Rheumatology, AP-HP Saint-Antoine Hospital, Paris, France
  3. 3Department of Rheumatology, Hospital de la Princesa, IIS-Princesa, Universidad Autónoma, Madrid, Spain
  1. Correspondence to Dr Gabriel Herrero-Beaumont, Bone and Joint Research Unit, IIS-Fundación Jiménez Díaz, Avda Reyes Católicos 2, 28040 Madrid, Spain; gherrero{at}


Experimental and clinical data support the hypothesis that both high and low bone mineral density (BMD) conditions, including osteoporosis, may induce osteoarthritis. However, these conditions do not always predispose to osteoarthritis progression. Four clinical settings could arise from this relationship, and furthermore two phenotypes may be identified whether early osteoarthritis coexists with high or low BMD.

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


  • Funding This work was supported by research grants from Spanish Instituto de Salud Carlos III PS09/01625 and PS09/0034, awarded to GH-B and RL.

  • Competing interests None.

  • Provenance and peer review Not commissioned; externally peer reviewed.