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Deoxyribonuclease II (DNASE2) is a lysosomal enzyme responsible for degrading DNA released from cells during erythropoiesis or apoptosis.1 DNASE2 mouse knockouts develop chronic polyarthritis similar to human rheumatoid arthritis (RA), including rheumatoid factor (RF).2 Association has been reported between three single nucleotide polymorphisms (SNPs; rs11085823, rs12609744 and rs249143) in tight linkage disequilibrium within the DNASE2 promoter and RA in German Caucasian samples, with differential association according to RF status.3
With the aim of replicating the previous findings,3 rs12609744, chosen because HapMap data were available for imputation, was genotyped using a TaqMan assay (Applied Biosystems, Foster City, California, USA) in New Zealand and UK Caucasian case-control samples,4 5 and imputed genotype data retrieved from a genome-wide scan (table 1).6 No evidence for association was found in any of the sample sets (OR 0.93–0.99, p=0.27–0.97) (table 1). In meta-analysis using a …
Funding Health Research Council of New Zealand, Arthritis New Zealand, University of Oxford
Competing interests None.
Ethical approval Ethical approval for the study in New Zealand was given by the New Zealand Multi-region Ethics Committee and the Lower South Ethics Committee, and in the UK by the Oxford Research Ethics Committee. All subjects gave written informed consent.
Provenance and peer review Not commissioned; externally peer reviewed.
The first two authors contributed equally to this work.
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