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Extended report
Rates and predictors of radiographic sacroiliitis progression over 2 years in patients with axial spondyloarthritis
  1. Denis Poddubnyy1,
  2. Martin Rudwaleit2,
  3. Hildrun Haibel1,
  4. Joachim Listing3,
  5. Elisabeth Märker-Hermann4,
  6. Henning Zeidler5,
  7. Jürgen Braun6,
  8. Joachim Sieper1
  1. 1Department of Rheumatology, Charité–Campus Benjamin Franklin, Berlin, Germany
  2. 2Department of Rheumatology, Evangelisches Krankenhaus Hagen-Haspe, Hagen, Germany
  3. 3Department of Epidemiology, German Rheumatism Research Centre, Berlin, Germany
  4. 4Dr Horst Schmidt Kliniken, Wiesbaden, Germany
  5. 5Medizinische Hochschule Hannover, Hannover, Germany
  6. 6Rheumazentrum Ruhrgebiet, Herne, Germany
  1. Correspondence to Joachim Sieper, Medical Department I, Rheumatology, Charité–Campus Benjamin Franklin, Hindenburgdamm 30, 12203 Berlin, Germany; joachim.sieper{at}


Objective To assess the progression of radiographic sacroiliitis in a cohort of patients with early axial spondyloarthritis over a period of 2 years and to explore predictors of progression.

Methods 210 patients with axial spondyloarthritis from the German Spondyloarthritis Inception Cohort have been selected for this analysis based on availability of radiographs at baseline and after 2 years of follow-up. Radiographs were centrally digitised and the sacroiliac joints were scored independently according to the grading system of the modified New York criteria for ankylosing spondylitis (AS) by two trained readers. The readers scored both time points simultaneously but were blinded for the time point and for all clinical data.

Results 115 patients (54.8%) fulfilled the modified New York criteria for AS in their radiographic part in the opinion of both readers at baseline, while 95 patients (45.2%) were classified as non-radiographic axial spondyloarthritis. More patients with non-radiographic spondyloarthritis (10.5%) compared with AS (4.4%) showed an estimated ‘true’ progression by at least one grade according to both readers, although the difference between the two groups was statistically non-significant. The rate of progression from non-radiographic axial spondyloarthritis to AS was 11.6% over 2 years. An elevated level of C-reactive protein (CRP) at baseline was a strong positive predictor of radiographic sacroiliitis progression in non-radiographic axial spondyloarthritis and AS (OR 3.65 and 5.08, respectively, p<0.05).

Conclusion Progression of radiographic sacroiliitis by at least one grade after 2 years occurs only in a small percentage of patients with early axial spondyloarthritis. An elevated level of CRP was found to be a strong positive predictor of sacroiliitis progression.

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  • Funding As part of the German competence network in rheumatology (Kompetenznetz Rheuma), GESPIC has been financially supported by the German Ministry for Education and Research (Bundesministerium für Bildung und Forschung–BMBF), grant number: FKZ01G19946. As funding by BMBF was reduced according to schedule in 2005, complementary financial support in equal parts has been obtained since 2005 from Amgen, Centocor, Schering-Plough and Wyeth, and since 2006 also from Abbott Immunology.

  • Competing interests None.

  • Patient consent Obtained.

  • Ethics approval The study protocol was approved by the central ethical committee of the coordinating centre (Charité–Campus Benjamin Franklin, Berlin, Germany) and by all local ethical committees of the participating centres.

  • Provenance and peer review Not commissioned; externally peer reviewed.