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Animal models for arthritis: innovative tools for prevention and treatment
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- Published on: 13 April 2016
- Published on: 13 April 2016Bone appearance in human tumor necrosis factor transgenic mice model: A model of rheumatoid arthritis or of hyperparathyroidism?Show More
Dear Editor,
Kollias et al. [1] presented an eloquent discussion of animal models of arthritis, remarking on their imperfect modeling of rheumatoid arthritis.
Among the models discussed was the human tumor necrosis factor (TNF) transgenic mice model. Examination of images of bone damage2 in this model3 suggested a previously unrecognized, intriguing effect/role of TNF. We use the phrase bone damage, as the most imp...Conflict of Interest:
None declared.