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Extended report
Chondroitin sulphate reduces both cartilage volume loss and bone marrow lesions in knee osteoarthritis patients starting as early as 6 months after initiation of therapy: a randomised, double-blind, placebo-controlled pilot study using MRI
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  • Published on:
    Response to eLetter by Felson and collaborators
    • Jean-Pierre Pelletier, Professor of Medicine, Head - Arthritis Division, University of Montreal, Director - Osteoarthritis
    • Other Contributors:
      • Johanne Martel-Pelletier, Lukas Martin Wildi, Jean-Pierre Raynauld, Andre Beaulieu, Louis Bessette, Frederic Morin, Francois Abram, and Marc Dorais,

    Dear Editor,

    In response to the eLetter of Felson and collaborators, we wish to point out that the methodologies used in the present study have been extensively validated and found to be reliable in the context of multicenter clinical trials [1-3]. Most of the comments made by Felson and collaborators reflect their experience from observational studies which may or may not apply to clinical trials.

    Regarding the...

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    Conflict of Interest:
    None declared.