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Coincidence of calcium pyrophosphate and monosodium urate crystals in the synovial fluid of patients with gout determined by the cytocentrifugation technique
  1. C Robier1,
  2. M Neubauer1,
  3. F Quehenberger2,
  4. F Rainer1
  1. 1Department of Internal Medicine, Hospital Barmherzige Brueder, Graz-Eggenberg, Austria
  2. 2Institute of Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria
  1. Correspondence to Christoph Robier, Department of Internal Medicine, Hospital Barmherzige Brueder, Graz-Eggenberg, Bergstrasse 27, A-8020 Graz, Austria; christoph.robier{at}

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Monosodium urate (MSU) crystals are pathognomonic for gout, whereas calcium pyrophosphate dihydrate crystals (CPPD) are the typical morphological substrate of chondrocalcinosis (CC).1 2 CC is frequently associated with osteoarthritis (OA) but does not appear to cause advanced cartilage damage.3 The clinical implication of CPPD crystal deposition in OA is still unknown.4 Furthermore, it has been shown that OA predisposes to the formation of MSU crystals at the osteoarthritic joint site.5 In a previous retrospective trial without the use of cytoconcentration techniques, a coincidence of MSU and CPPD crystals was found in 17/4620 examined synovial fluid (SF) specimens.6 Data on the simultaneous occurrence of both crystal types using cytocentrifuges, which can improve the sensitivity of crystal detection compared with commonly used methods, are lacking. …

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  • Competing interests None.

  • Ethics approval This study was approved by the institutional ethics committee of the Hospital Barmherzige Brueder in Graz-Eggenberg, Austria.

  • Provenance and peer review Not commissioned; externally peer reviewed.