Objective To compare current definitions of remission and relapse in polymyalgia rheumatica (PMR) with items resulting from a Delphi-based expert consensus.
Methods Relevant studies including definitions of PMR remission and relapse were identified by literature search in PubMed. The questionnaire used for the Delphi survey included clinical (n=33), laboratory (n=54) and imaging (n=7) parameters retrieved from a literature search. Each item was assessed for importance and availability/practicability, and limits were considered for metric parameters. Consensus was defined by an agreement rate of ≥80%.
Results Out of 6031 articles screened, definitions of PMR remission and relapse were available in 18 and 34 studies, respectively. Parameters used to define remission and/or relapse included history and clinical assessment of pain and synovitis, constitutional symptoms, morning stiffness (MS), physician's global assessment, headache, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), blood count, fibrinogen and/or corticosteroid therapy. In the Delphi exercise a consensus was obtained on the following parameters deemed essential for definitions of remission and relapse: patient's pain assessment, MS, ESR, CRP, shoulder and hip pain on clinical examination, limitation of upper limb elevation, and assessment of corticosteroid dose required to control symptoms.
Conclusions Assessment of patient's pain, MS, ESR, CRP, shoulder pain/limitation on clinical examination and corticosteroid dose are considered to be important in current available definitions of PMR remission and relapse and the present expert consensus. The high relevance of clinical assessment of hips was unique to this study and may improve specificity and sensitivity of definitions for remission and relapse in PMR.
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Polymyalgia rheumatica (PMR) is a common disease in older people conventionally treated with long-term oral corticosteroids.1,–,6
As corticosteroid treatment leads to rapid improvement in symptoms and returns patients to pre-morbid functional status, interventional studies in PMR usually focus on parameters such as ‘complete remission’ or ‘time in remission to relapse’, rather than on partial response criteria used in other immune-mediated diseases.7,–,10 However, there is still considerable uncertainty related to definitions of ‘remission’ and ‘relapse’ in PMR, with disparate use of criteria used to define these disease states in PMR treatment studies to date.
New definitions of remission and relapse have been proposed by Leeb et al11 and Binard et al,12 respectively. Both definitions were based on the PMR activity score (PMR-AS), which was developed using predefined parameters and was not subject to a consensus finding process including a systematic literature review.13 14The validity of the PMR-AS has been supported in a number of studies.11 12 15 16
This paper presents the results from a Delphi-based consensus survey involving rheumatologists (RMs) and general practitioners (GPs) identifying candidate items for new definitions of remission and relapse. We compared these parameters with currently available remission and relapse definitions retrieved from a systematic literature review.
A literature search was conducted in PubMed, Medline (from January 1966 to November 2003, updated June 2009), using the items ‘Polymyalgia rheumatica’, ‘PMR’, ‘Giant cell arteritis’, ‘Polymyalgia rheumatica AND Remission’ and ‘Polymyalgia rheumatica AND Relapse’ as keywords. Only studies written in English were included. All studies were screened for definitions of remission and/or relapse of PMR and parameters used to define these conditions in PMR.
We used a two-step Delphi process. Firstly, we generated a questionnaire with candidate items for definitions of remission and relapse of PMR as retrieved in a literature search. The final questionnaire included 94 items categorised into ‘history’ (n=19), ‘physical examination’ (n=14), ‘laboratory findings’ (n=54) and ‘imaging methods’ (n=7). One questionnaire each was used to assess the definition of remission on treatment medication (reflecting short-term response to corticosteroids), remission off medication (longer-term outcome after withdrawal of corticosteroids) and relapse (when the patient is still taking corticosteroids). Availability and practicability of all criteria were separately assessed. In the first round, experts indicated the importance (‘essential’, ‘less important’ or ‘not important’) and availability/practicability (‘routinely available/practicable’, ‘not always available/difficult to perform’ or ‘not available/practicable’) of diagnostic tools. Availability of diagnostic tools was examined in this round only. Experts were encouraged to add further candidate criteria to be considered for assessment and relevant comments. In addition, experts were asked to suggest cut-off points for the proposed quantitative candidate criteria items based on data from the literature review. Questionnaires were distributed to all experts via mail or e-mail. Experts were contacted by telephone and/or reminders were sent to encourage participation and return of questionnaires.
The questionnaire used in the second round was derived from that of the first round using results from the first round. Parameters considered ‘not available’ or ‘not important’ by ≥50% or ‘essential’ by <20% of experts were excluded. Items regarded as essential by ≥80% of experts for the definition of remission and/or relapse were accepted as consensus items and not further assessed. First-round results of the remaining parameters were illustrated to the experts by pie diagrams. Then, experts were asked to re-evaluate the parameters either as ‘important’ or ‘not important’ to the definition of remission and/or relapse of PMR. In addition, experts were encouraged to choose a limit for quantitative items among those proposed in the first round. All written comments were attached anonymously.
As first-round analysis of questionnaires for remission ‘on medication’ and ‘off medication’ showed almost perfect agreement, no separate assessment for remission ‘on medication’ and ‘off medication’ was performed in the second round. Only the parameter ‘patient's assessment of pain related to neck, upper arms, shoulders and pelvic girdle by a visual analogue scale (VAS)’ revealing some disagreement was reassessed.
We invited 25 RMs from Europe (Italy (n=6), Sweden (n=1), UK (n=2), France (n=1), Austria (n=3), Spain (n=2), Germany (n=3)), Israel (n=1) and the USA (n=6) experienced in treatment and research of PMR to participate. Most of them are members of the International Work Group for PMR and GCA.17RMs were asked to propose one GP experienced in treating patients with PMR and willing to participate in the study.
Statistical analyses were performed using SPSS, V.11.0. Responses were analysed by descriptive statistics as appropriate. Invalid or missing data were excluded.
Of 6031 articles screened, 1851 were excluded because they were written in a language other than English, and 2500 reports were editorials, comments, or letters without original data. Of the 1680 remaining papers, we identified 18 and 34 that contained definitions of PMR remission and relapse, respectively: one paper each with a definition of PMR remission and relapse based on PMR-AS (table 1) and an additional 17 and 33 papers containing remission and relapse criteria not based on PMR-AS, respectively (tables 2 and 3).
Responses by invited physicians to the first round of questionnaires were 34/50 (25 RMs (100%) and nine GPs (36%)) and to the second round 22/34 (19 RMs (76%) and three GPs (12%)). Owing to the low response rate from GPs, we restricted our final analyses of both questionnaire rounds to results derived from RMs. The omission of data from GPs did not significantly alter the results of the Delphi exercise. Pooled data for RMs and GPs are shown in online supplementary tables 1b, 2b, 3b and 4.
Results of the first questionnaire round
After the first questionnaire round, 64 out of 94 parameters were considered ‘not important’ for the definition of remission, and 65/94 were considered ‘not important’ for defining relapse by the majority of RMs. The 64 parameters for remission included 6/19 from the category history, 2/14 from physical examination, 50/54 from laboratory findings, and 6/7 from imaging methods. The 65 parameters considered not important for defining relapse included 7/19 from history, 2/14 from physical examination, 50/54 from laboratory findings, and 6/7 from imaging methods.
Questionnaires related to remission ‘on medication’ and ‘off medication’ showed very high agreement (κ 0.93). Data from both questionnaires led to exclusion or consensus on the same parameters except for the parameter ‘patient's assessment of pain related to neck, upper arms, shoulders and pelvic girdle by a VAS’, which was considered to be essential by 81.8% of RMs for ‘remission on medication’ (=consensus), and by 79.2% for ‘remission off medication’.
Availability of items for definitions of remission and relapse
Of 94 parameters from the literature, 29 were considered as routinely available/practicable by more than 80% of RMs (10/19 parameters out of the category history, 12/14 out of clinical examination, 7/54 out of laboratory findings, and 0/7 out of imaging methods) (see online supplementary tables 1a and 2a for detailed results).
Eight parameters (all blood tests for cytokines or cytokine receptors) were considered to be not available.
Results of the second questionnaire round
Tables 4 (remission) and 5 (relapse) depict those items for which RMs achieved a consensus following the two Delphi rounds. The limits for metric parameters were proposed in the first questionnaire round and rated in the second round.
Assessment of symmetric synovitis with peripheral oedema as seen in RS3PE (remitting seronegative syndrome with pitting oedema), peripheral arthritis, patient's and physician's global assessment, history of transient visual symptoms, fever and physician's pain assessment were important for >50% of RMs in defining remission and relapse in both questionnaire rounds but did not reach consensus level (see online supplementary table 3a for detailed results).
Comparison of parameters resulting from Delphi exercise with previous definitions of remission and relapse of PMR
Previous definitions of remission and relapse not based on PMR-AS included the parameters patient's assessment of pain (29.4% and 21.2%, respectively), MS (23.5% and 21.2%, respectively), ESR (70.6% and 60.6%, respectively), CRP (29.4% and 30.3%, respectively) and shoulder pain/limitation on clinical examination (11.8% and 0%, respectively); and these parameters also reached consensus level in the Delphi exercise and are included in the PMR-AS (ESR may be used instead of CRP according to the original work by Leeb et al13 14). Physician's global assessment is part of the PMR-AS, but did not achieve consensus level in the Delphi study with 57.9% and 56.2% agreement for remission and relapse, respectively. Assessment of corticosteroid dose (remission)/response to corticosteroids (relapse) and hip symptoms judged to be important by >80% of experts in the Delphi survey are not part of the PMR-AS and were specifically included in 17.6% and 11.8% of previous definitions of remission, respectively, and 60.6% and 12.1% of previous definitions of relapse, respectively, not based on PMR-AS. Peripheral synovitis, patient's global assessment, history of transient visual symptoms, history of fever, and physician's pain assessment were all important for the majority of RMs in the Delphi exercise, but are considered by <6% of previous remission and relapse definitions including the PMR-AS.
This international Delphi survey among RM experts corroborated some previously proposed items for the definition of PMR remission and relapse including patient's assessment of pain, MS, ESR, CRP, shoulder pain/limitation on clinical examination, and corticosteroid dose required to control symptoms. Many other items, such as determination of haemoglobin and fibrinogen, were considered to have little value for this purpose.
The consensus on hip involvement was unexpected, as this parameter was only considered in 2/17 and 4/33 previous studies with definitions of remission and relapse, respectively, and was not included in the PMR-AS. In addition, we observed a high relevance (>50% agreement) of peripheral manifestations and fever compared with previous literature. Hips are involved in 50–70% of patients with PMR, and peripheral or constitutional symptoms occur in 30–50%.18Assessment of these clinical features with incorporation into definitions of remission and relapse may lead to higher specificity and sensitivity of these definitions and possibly allow improved classification of those 10–30% of patients who lack shoulder symptoms.18
Clear improvement in, or flare of, PMR using clinical symptoms such as pain or MS was considered to be important by experts in the present survey. These parameters are included in the PMR-AS, and most proposed remission and/or relapse definitions in the current literature. However, this international PMR/GCA study group recently questioned the value of MS, as patients and clinicians may not reliably distinguish between pain and stiffness.17 A major concern is that pain-related items may lack specificity given the high prevalence of osteoarthritis and degenerative pain in older people.19 The occurrence of unilateral versus bilateral pain may be useful in this regard; however, a prospective study is needed to clarify the true value of pain and stiffness in defining remission and relapse in PMR.
The biometric limits for clinical items (eg, duration of MS) chosen by experts in the present survey were comparable to those available from a literature search and the PMR-AS. In the present Delphi survey and previous definitions of remission and relapse, cut-off values were preferred to relative changes in the parameters during follow-up. A relevant consideration in this regard is that all such measures should be zero for a PMR patient in remission. However, many older patients with arthritic/rheumatic conditions rarely consider themselves to be completely free from pain and stiffness.20 Therefore, several PMR studies define remission pragmatically as absence of relapse or as duration of relapse-free survival, accepting higher (non-zero) biometric limits for patients in remission.21,–,25 This strategy for defining remission has the advantage of a high sensitivity, classifying all patients with PMR as either in remission or relapse. In contrast, developing separate remission and relapse criteria results in a high specificity of classification, but suggests an additional (yet undefined) disease state that is neither remission nor relapse. Sensitivity and specificity of such definitions may differ, if relevant parameters are used as a qualitative set of criteria or a composite score, such as the PMR-AS. In rheumatoid arthritis and other rheumatic diseases, composite scores are usually preferred, whereas most treatment studies in PMR to date have used qualitative sets of criteria. The question of which approach is more useful for daily clinical practice and outcome studies remains to be addressed by future studies.
In this Delphi exercise, both ESR and CRP were assumed to be routinely available and to be the most promising laboratory items for defining both remission and relapse. While CRP is a component of the PMR-AS, other published studies have preferentially used a normal ESR as a component of their remission definition. Persistently raised CRP has been suggested to correlate better with inflammation in PMR than ESR and may thus be better suited for use in definitions of remission and relapse.26 An important limitation of CRP and ESR is that these may be normal (not increased) in up to 20% of patients with PMR at the time of diagnosis.18 Indeed, normal ESR or CRP values have been observed in up to 27% and 14% of relapses, respectively, despite the increase in these parameters at the time of diagnosis.10 27,–,29 Thus a flare of PMR symptoms may occur in the absence of abnormal inflammatory parameters, although degenerative pain with stiffness may also mimic a flare of the disease.
A relapse of PMR can be defined even with normal CRP and/or ESR using the PMR-AS and definitions from 22 of the 33 other studies from the literature search. Notably, the PMR-EULAR response criteria that provide the basis for the PMR-AS were developed in a cohort of PMR patients who all had raised ESR and CRP values at the time of diagnosis.13 In the present survey, the possibility of relapse in the absence of abnormally increased ESR and/or CRP was not addressed and requires future clarification.
The other laboratory parameters evaluated, including blood count, markers of vascular damage/activation, hormones and cytokines/receptors, were considered less important in evaluating relapse and remission at this point in time.
Corticosteroids are the mainstay of treatment for PMR, although the optimal initial dose and tapering regimen are matters of ongoing debate.1 30,–,32 Assessment of corticosteroid dose may be important to the definition of remission. A related consideration is that physicians and patients may be unwilling to accept the status of ‘remission’ if achieved at the expense of serious impairment of the patient's general well-being due to side effects of unacceptably high corticosteroid doses.11 Maintaining a treatment-free complete clinical response after stopping treatment remains the clinical goal, which is not always achievable in PMR.11 33
In the present survey, >80% of experts were of the opinion that corticosteroid doses should be included in any definition of remission in PMR. While agreeing that the corticosteroid dose ‘should be as low as possible’, a specified dose limit was not agreed upon. A prospective study would be needed to clarify whether the assessment of corticosteroid doses improves the specificity of a definition of remission.
The majority of experts thought that the need for any increment in corticosteroid dose necessary to control PMR symptoms should be included in the criteria for defining relapse. This result is in accordance with 20 studies from our literature search, which considered a flare of PMR symptoms to be a relapse if symptoms respond to an increased dose of corticosteroid.
To address possible differences related to useful parameters for assessing short-term (ie, remission when the patient is taking corticosteroids) and long-term (ie, remission after treatment withdrawal) outcomes in PMR, we used different questionnaires to define remission ‘on medication’ and ‘off medication’. The ratings of the two questionnaires showed almost perfect agreement, indicating that the same clinical parameters may be useful for defining both states of remission. However, we did not address the role of time with respect to remission, as has been reported previously.30 31 34,–,37 The time in remission after withdrawal of treatment is of particular interest in distinguishing patients in ‘permanent’ remission or at low risk of relapse from those at high risk of relapse.28 38 This issue remains to be clarified.
We invited 50 experts to participate in this Delphi exercise, recognising that no optimal number of experts for such a study exists. The reliability of results may decline rapidly with fewer than six panel members, whereas improvements in reliability are relatively small in groups larger than 15.39 40 There is also no definition of an ‘expert’ status for a Delphi study, but, as PMR is diagnosed by RMs and GPs, we sought to consider opinions of both groups of physicians. A survey among French GPs revealed that only 36% of GPs routinely refer PMR patients to a RM for diagnosis of the disease and that only 20% of these GPs take advice from RMs for routine follow-up of PMR patients.15 Therefore we asked participating RMs to recommend one GP each in order to involve an international group of GPs with adequate experience in rheumatology. Only nine and three GPs responded to the first and second questionnaire rounds, respectively, despite recurrent telephone contacts and/or written reminders. The low response rate for GPs limits the validity of their responses, and therefore we restricted our final analysis to data derived from RMs. The omission of data from GPs, however, did not significantly alter the results.
The two rounds of questionnaires resulted in a quite limited number of parameters being accepted by the majority of experts. Many others did not achieve the predefined level of consensus. It is possible that another round addressing at least some of these items further may have resulted in them being classified as consensus items or as not important. Further rounds of questionnaires were not pursued, in part because of concern that respondent fatigue might seriously erode the value of the exercise.
The items that emerged from this Delphi-based expert consensus as important for defining relapse and remission in patients with PMR were patient's assessment of pain related to neck, upper arms, shoulders and pelvic girdle, MS, ESR, CRP, shoulder pain/limitation on clinical examination, and corticosteroid dose. Clinical assessment of the hips turned out to be important in this survey and may further improve specificity and sensitivity of defining remission and relapse in PMR. The operating characteristics and value of the remission and relapse items derived in this exercise will require prospective evaluation.
Participating rheumatologists of the Delphi survey and members of the International Work Group for PMR and GCA:
Kenneth Calamia, Division of Rheumatology, Mayo Clinic College of Medicine, Jacksonville, FL, USA; Roberto Caporali, University of Pavia, IRCCS S Matteo Foundation, Pavia, Italy; Marco A. Cimmino, Department of Internal Medicine, University of Genova, Genova, Italy; Bhaskar Dasgupta, Department of Rheumatology, Southend University Hospital, Essex, United Kingdom; William Docken, Brigham Orthopedics and Arthritis Center, Chestnut Hill, MA, USA; Pierre Duhaut, Department of Internal Medicine, CHU Nord, Amiens, France; Miguel A Gonzalez-Gay, Division of Rheumatology, Hospital Xeral-Calde, Lugo, Spain; Roberto Gerli, Rheumatology Unit, Department of Clinical & Experimental Medicine, University of Perugia, Perugia, Italy; Manfred Herold, Department of Internal Medicine I, Innsbruck Medical University, Innsbruck, Austria; Gery S. Hoffman, Department of Rheumatic and Immmunologic Diseases, Cleveland Clinic Lerner College of Medicine, Cleveland, OH, USA; Eugene Kissin, Boston University Medical Center, Boston, MA, USA; Peter Lamprecht, Department of Rheumatology, Vasculitis Center UKSH & Clinical Center Bad Bramstedt, University of Lübeck, Lübeck, Germany; Burkhart Leeb, Lower Austrian Center for Rheumatology, Stockerau, Austria; Pierluigi Macchioni, Department of Rheumatology, Arcispedale Santa Maria Nouva, Reggio Emilia, Italy; Victor Martinez-Taboada, Division of Rheumatology, Hospital Marques de Valdecilla, Santander, Spain; Eric L. Matteson, Division of Rheumatology, Mayo Clinic, Rochester, MN, USA; Peter A Merkel, Division of Rheumatology, Boston University, Boston, MA, USA; Carlo M. Montecucco, University of Pavia, IRCCS S Matteo Foundation, Pavia, Italy; Gideon Nesher, Department of Internal Medicine, Shaare Zedek Medical Center, Jerusalem, Israel; Elisabeth Nordborg, Institute of Rheumatology, Huddinge University Hospital, Stockholm, Sweden; Colin Pease, Rheumatology and Rehabilitation Research Unit, University of Leeds, Leeds, UK; Carlo Salvarani, Department of Rheumatology, Arcispedale S. Maria Nuova, Reggio Emilia, Italy; Michael Schirmer, Department of Internal Medicine I, Innsbruck Medical University, Innsbruck, Austria; Wolfgang Schmidt, Department of Rheumatology, Berlin-Buch, University of Berlin, Berlin, Germany; Roberto Spierra, Beth Israel Medical Center, New York, NY, USA; Annette Wagner, Department of Rheumatology, University of Hannover, Hannover, Germany.
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Competing interests None.
Provenance and peer review Not commissioned; externally peer reviewed.