Article Text

Download PDFPDF
Extended report
Diagnostic accuracy of enthesis ultrasound in the diagnosis of early spondyloarthritis
  1. Eugenio de Miguel1,
  2. Santiago Muñoz-Fernández2,
  3. Concepción Castillo1,
  4. Tatiana Cobo-Ibáñez2,
  5. Emilio Martín-Mola1
  1. 1Rheumatology Unit, Hospital Universitario La Paz, Madrid, Spain
  2. 2Rheumatology Unit, Hospital Infanta Sofía, Madrid, Spain
  1. Correspondence to Dr Eugenio de Miguel, Rheumatology Unit, Hospital Universitario La Paz, Pº de la Castellana 261, 28046 Madrid, Spain; eugenio.demiguel{at}


Objective To determine the sensitivity and specificity of enthesis ultrasound for the diagnostic classification of early spondyloarthritis.

Methods A cross-sectional, blinded and controlled study. Standardised bilateral ultrasound of six entheses (Madrid sonography enthesitis index (MASEI)) was performed. Accepted diagnostic classification criteria were used as the gold standard. Validity was analysed by receiver operating characteristic (ROC) curves. Values of p<0.05 were considered significant.

Results 113 early spondyloarthritis patients were included (58 women/55 men), 57 non-inflammatory control individuals (29 women/28 men) and 24 inflammatory control individuals (11 women/13 men). The evolution time of spondyloarthritis was 10.9±7.1 months. At least some grade of sacroiliitis on x-ray was present in 59 patients, but only five fulfilled the radiographic sacroiliitis New York criteria. Human leucocyte antigen B27 (HLA-B27) was positive in 42% of patients. No statistical differences were found for the enthesis score among diagnostic spondyloarthritis subtypes form of presentation (axial, peripheral or mixed) or HLA-B27 positivity. The MASEI score achieved statistical significance for gender. The ultrasound score was 23.36±11.40 (mean±SD) in spondyloarthritis patients and 12.26±6.85 and 16.04±9.94 in the non-inflammatory and inflammatory control groups (p<0.001), respectively. The ROC area under the curve was 0.82, and a cut-off point of ≥20 points achieved a likelihood ratio of 5.30 and a specificity of 89.47%.

Conclusions Entheses are affected early in spondyloarthritis, and the incidence of involvement is higher in men and independent of the spondyloarthritis diagnostic subtype, HLA-B27 status or presentation pattern. The enthesis ultrasound score seems to have diagnostic accuracy and may be useful for improving the diagnostic accuracy of early spondyloarthritis.

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


  • Funding This study was supported by an unrestricted grant from Spanish Rheumatology Foundation and Pfeizer (ESPERANZA programme).

  • Patient consent Obtained.

  • Ethics approval This study was conducted according to local regulations and the Declaration of Helsinki, and local approval was obtained from the ethical committee and institutional review board of the Hospital Universitario La Paz, Madrid, Spain.

  • Provenance and peer review Not commissioned; externally peer reviewed.