Inflammation of synovium is one of the hallmarks of rheumatoid arthritis (RA). Analysis of synovial tissue has increased our understanding of RA pathogenesis, aided in identifying potential therapeutic targets and has been used in the response and mechanistic evaluation of antirheumatic treatments. In addition, studies are ongoing, aimed at the identification of diagnostic and prognostic biomarkers in the synovium. This paper outlines the currently used procedures for sampling and processing of synovial tissue, and presents a standardised recommendation to support multicentre translational research.
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Funding This research was supported by the European Community's FP6 funding (AutoCure) and the Dutch Arthritis Association (Reumafonds), the EULAR Synovitis Study Group and the OMERACT Special Interest Group on Synovial Analysis in Clinical Trials. SA, VC, IF and EV-S participated in the University of Glasgow/Academic Medical Center-University of Amsterdam Inflammatory Arthritis Fellowship sponsored by NovoNordisk.
Competing interests None.
Provenance and peer review Commissioned; externally peer reviewed.
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